Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.45 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.45 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5881345 | 0.83 | ALDH1A1 (0.49) | TSHRNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL28050912 | 0.75 | TSHR (0.77) | TSHRNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL341320 | 0.74 | TXNRD1 (0.60) | TSHRNPC1RAB9ATXNRD1TXNRD3 | |
| SCHEMBL6625108 | 0.72 | PDGFRB (0.50) | TSHRNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL27576986 | 0.72 | TSHR (0.52) | TSHRNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL10748411 | 0.71 | TXNRD1 (0.52) | TSHRNPC1RAB9ATXNRD1TXNRD3 | |
| SCHEMBL10749290 | 0.70 | TXNRD1 (0.62) | NPC1RAB9ATXNRD1TXNRD3TXNRD2 | |
| Acetic Acid SCHEMBL27685581 | 0.69 | TSHR (0.67) | TSHRNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL5981573 | 0.69 | TSHR (0.71) | TSHRNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL5155427 | 0.69 | TSHR (0.66) | TSHRNPC1RAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053082-B1 | 2,3-benzodiazepine derivatives | EGIS GYOGYSZERGYAR RT. (HU) | 2006-05-30 | — | — | US | disclosed |
| EP-1200442-B8 | 2,3-BENZODIAZEPINE DERIVATIVES | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 2003-08-20 | — | — | EP | disclosed |
| EP-1200442-B1 | 2,3-BENZODIAZEPINE DERIVATIVES | EGIS GY GYSZERGY R RT (HU) | 2003-06-25 | — | — | EP | disclosed |
| EP-1200442-A1 | 2,3-BENZODIAZEPINE DERIVATIVES | Egis Gyogyszergyar Rt. (HU) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001004122-A2 | NEW 2,3-BENZODIAZEPINE DERIVATIVES | EGIS Gyógyszergyár Rt. (HU) | 2001-01-18 | — | — | WO | disclosed |