Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | PELP1 | Q8IZL8 | 1/20 | 0.46 |
| ▸ | USP10 | Q14694 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.45 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4753199 | 0.86 | VCAM1 (0.60) | VCAM1KMT2AARPELP1ALDH1A1 | |
| SCHEMBL1353346 | 0.84 | VCAM1 (0.57) | VCAM1ALDH1A1HPGDNPSR1LMNA | |
| SCHEMBL30304316 | 0.82 | VCAM1 (0.56) | VCAM1KMT2AARPELP1ALDH1A1 | |
| SCHEMBL11330293 | 0.82 | VCAM1 (0.56) | VCAM1ARPELP1ALDH1A1HPGD | |
| SCHEMBL19046539 | 0.81 | VCAM1 (0.55) | VCAM1KMT2AARPELP1USP10 | |
| SCHEMBL18013199 | 0.81 | VCAM1 (0.61) | VCAM1KMT2AARPELP1USP10 | |
| SCHEMBL5734347 | 0.80 | VCAM1 (0.68) | VCAM1KMT2AALDH1A1HPGDNPSR1 | |
| SCHEMBL4273530 | 0.79 | SMN1; SMN2 (0.52) | KMT2AALDH1A1HPGDLMNAMAPT | |
| SCHEMBL2722007 | 0.79 | VCAM1 (0.56) | VCAM1ARPELP1USP10ALDH1A1 | |
| SCHEMBL19329160 | 0.79 | KDM4E (0.57) | KMT2AALDH1A1HPGDLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115647-B2 | Method of inhibiting neoplastic cells with indole derivatives | OSI PHARMACEUTICALS, INC. (US) | 2006-10-03 | — | — | US | disclosed |
| US-20020143022-A1 | Method of inhibiting neoplastic cells with indole derivatives | OSI PHARMACEUTICALS, INC. | 2002-10-03 | — | — | US | disclosed |
| US-6410584-B1 | ANTICANCER AGENTS | CELL PATHWAYS, INC. | 2002-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020143022-A1 | Method of inhibiting neoplastic cells with indole derivatives | IDO1, IDO2, INMT | VCAM1 2038/4885KMT2A 1949/4885AR 1527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.