Lobeglitazone

Lobeglitazone

SCHEMBL2742697

COc1ccc(Oc2cc(N(C)CCOc3ccc(CC4SC(=O)NC4=O)cc3)ncn2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PPARG P37231 18/20 1.00
PPARA Q07869 2/20 1.00
RXRA P19793 2/20 0.56
RARG P13631 1/20 0.56
FFAR1 O14842 3/20 0.50
MPC2 O95563 1/20 0.49
CYP2C8 P10632 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP3A4 P08684 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lobeglitazone SCHEMBL29356140 1.00 PPARG (1.00) PPARGPPARARXRARARGFFAR1
Lobeglitazone SCHEMBL20125583 1.00 PPARG (1.00) PPARGPPARARXRARARGFFAR1
Lobeglitazone SCHEMBL20125580 1.00 PPARG (1.00) PPARGPPARARXRARARGFFAR1
Lobeglitazone SCHEMBL29778221 0.97 PPARG (1.00) PPARGPPARARXRARARGFFAR1
SCHEMBL5884045 0.93 PPARG (0.86) PPARGPPARARXRARARGFFAR1
SCHEMBL19454945 0.92 PPARG (0.85) PPARGPPARARXRARARGFFAR1
SCHEMBL5883617 0.86 PPARG (0.75) PPARGPPARARXRARARGFFAR1
SCHEMBL5884168 0.85 PPARG (0.74) PPARGPPARARXRARARGFFAR1
SCHEMBL5883649 0.84 PPARG (0.73) PPARGPPARARXRARARGFFAR1
SCHEMBL5883494 0.82 PPARG (0.69) PPARGPPARARXRARARGFFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 264 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024162731-A1 PHARMACEUTICAL COMPOSITE FORMULATION COMPRISING LOBEGLITAZONE AND SITAGLIPTIN CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2024-08-08 WO claimed
US-20230266340-A1 Measurement, Diagnosis, Treatment and Management of Metabolic Syndrome SILTI AG (CH) 2023-08-24 US claimed
EP-4688742-A1 CYCLOHEXYL OR HETEROCYCLOALKYL BETA-HYDROXY ALKYL AMINES FOR USE IN THE TREATMENT OF HYPERGLYCAEMIA AND DISORDERS CHARACTERISED BY HYPERGLYCAEMIA Atrogi AB (SE) 2026-02-11 EP disclosed
EP-4688766-A1 HETEROCYCLOALKYL BETA-HYDROXY ALKYL AMINES FOR USE IN THE TREATMENT OF HYPERGLYCAEMIA AND DISORDERS CHARACTERISED BY HYPERGLYCAEMIA Atrogi AB (SE) 2026-02-11 EP disclosed
EP-4688738-A1 HETEROCYCLOALKYL BETA-HYDROXY ALKYL AMINES FOR USE IN THE TREATMENT OF HYPERGLYCAEMIA AND DISORDERS CHARACTERISED BY HYPERGLYCAEMIA Atrogi AB (SE) 2026-02-11 EP disclosed
US-20250281507-A1 METHODS OF TREATING NEPHROTIC SYNDROME THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN’S HOSPITAL 2025-09-11 US disclosed
US-20250262209-A1 TREATMENT OF GASTROINTESTINAL DISEASES ACLIPSE TWO INC. 2025-08-21 US disclosed
US-12378216-B2 Heteroaryl(heterocyclyl)methanol compounds useful in the treatment of hyperglycaemia ATROGI AB (SE) 2025-08-05 US disclosed
US-20250223296-A1 HYDROXYMETHYL AZABICYCLO[2.2.1]HEPTANES AND MEDICAL USES THEREOF ATROGI AB (SE) 2025-07-10 US disclosed
US-20250221962-A1 FABP4 AS A THERAPEUTIC TARGET IN SKIN DISEASES TICURE LTD (IL) 2025-07-10 US disclosed
US-12280023-B2 Fluorophenyl beta-hydroxyethylamines and their use in the treatment of hyperglycaemia ATROGI AB (SE) 2025-04-22 US disclosed
WO-2009097997-A1 SUBSTITUTED IMIDAZOLIDINE-2,4-DIONES, METHOD FOR THE PRODUCTION THEREOF, MEDICAMENTS CONTAINING SAID COMPOUNDS AND USE THEREOF SANOFI-AVENTIS (FR) 2009-08-13 WO disclosed
WO-2009097995-A1 NOVEL PHENYL-SUBSTITUTED IMIDAZOLIDINES, METHOD FOR THE PRODUCTION THEREOF, MEDICAMENTS CONTAINING SAID COMPOUNDS AND USE THEREOF SANOFI-AVENTIS (FR) 2009-08-13 WO disclosed
WO-2009098000-A1 HETEROCYCLICALLY-SUBSTITUTED IMIDAZOLIDINE-2,4-DIONES, METHOD FOR THE PRODUCTION THEREOF, MEDICAMENTS CONTAINING SAID COMPOUNDS AND USE THEREOF SANOFI-AVENTIS (FR) 2009-08-13 WO disclosed
WO-2009097996-A1 USE OF SUBSTITUTED PHENYLIMIDAZOLIDINES FOR PRODUCING MEDICAMENTS FOR TREATING METABOLIC SYNDROME SANOFI-AVENTIS (FR) 2009-08-13 WO disclosed
WO-2009062619-A1 NEW CRYSTALLINE DIPHENYL ACETIDINONE HYDRATE, PHARMACEUTICAL AGENT CONTAINING SAID COMPOUND AND USE THEREOF SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2009-05-22 WO disclosed
WO-2009039942-A1 (CYCLOPROPYL-PHENYL)-PHENYL-OXALAMIDES, METHOD FOR THE PRODUCTION THEREOF, AND USE OF SAME AS A MEDICAMENT SANOFI-AVENTIS (FR) 2009-04-02 WO disclosed
WO-2009039943-A1 (CARBOXYLALKYLENE-PHENYL)-PHENYL-OXALAMIDES, METHOD FOR THE PRODUCTION THEREOF, AND USE OF SAME AS A MEDICAMENT SANOFI-AVENTIS (FR) 2009-04-02 WO disclosed
WO-2009021740-A2 SUBSTITUTED TETRAHYDRONAPHTHALENES, PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF AS MEDICAMENTS SANOFIS-AVENTIS (FR) 2009-02-19 WO disclosed
WO-2008052658-A1 NOVEL DIPHENYLAZETIDINONE SUBSTITUTED BY PIPERAZINE-1-SULFONIC ACID HAVING IMPROVED PHARMACOLOGICAL PROPERTIES SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2008-05-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250281507-A1 METHODS OF TREATING NEPHROTIC SYNDROME PPARA, PPARG, PPARD PPARG 2/4885PPARA 1/4885RXRA 60/4885
US-20250262209-A1 TREATMENT OF GASTROINTESTINAL DISEASES FABP6, SLC10A2, FABP2 PPARG 17/4885PPARA 40/4885RXRA 275/4885
US-12378216-B2 Heteroaryl(heterocyclyl)methanol compounds useful in the treatment of hyperglycaemia SLC5A1, GPR119, SLC5A2 PPARG 2017/4885PPARA 2978/4885RXRA 2442/4885
US-12280023-B2 Fluorophenyl beta-hydroxyethylamines and their use in the treatment of hyperglycaemia GPR119, SLC5A2, SLC5A1 PPARG 1271/4885PPARA 2022/4885RXRA 3655/4885
US-20250221962-A1 FABP4 AS A THERAPEUTIC TARGET IN SKIN DISEASES FABP4, FABP2, FABP1 PPARG 46/4885PPARA 50/4885RXRA 70/4885
US-20250223296-A1 HYDROXYMETHYL AZABICYCLO[2.2.1]HEPTANES AND MEDICAL USES THEREOF CYP3A5, CYP11B2, UGT1A1 PPARG 2017/4885PPARA 1778/4885RXRA 566/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.