Lobeglitazone

Lobeglitazone

SCHEMBL29356140

COc1ccc(Oc2cc(N(C)CCOc3ccc(CC4SC(=O)NC4=O)cc3)ncn2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PPARG P37231 18/20 1.00
PPARA Q07869 2/20 1.00
RXRA P19793 2/20 0.56
RARG P13631 1/20 0.56
FFAR1 O14842 3/20 0.50
MPC2 O95563 1/20 0.49
CYP2C8 P10632 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP3A4 P08684 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lobeglitazone SCHEMBL20125583 1.00 PPARG (1.00) PPARGPPARARXRARARGFFAR1
Lobeglitazone SCHEMBL20125580 1.00 PPARG (1.00) PPARGPPARARXRARARGFFAR1
Lobeglitazone SCHEMBL2742697 1.00 PPARG (1.00) PPARGPPARARXRARARGFFAR1
Lobeglitazone SCHEMBL29778221 0.97 PPARG (1.00) PPARGPPARARXRARARGFFAR1
SCHEMBL5884045 0.93 PPARG (0.86) PPARGPPARARXRARARGFFAR1
SCHEMBL19454945 0.92 PPARG (0.85) PPARGPPARARXRARARGFFAR1
SCHEMBL5883617 0.86 PPARG (0.75) PPARGPPARARXRARARGFFAR1
SCHEMBL5884168 0.85 PPARG (0.74) PPARGPPARARXRARARGFFAR1
SCHEMBL5883649 0.84 PPARG (0.73) PPARGPPARARXRARARGFFAR1
SCHEMBL5883494 0.82 PPARG (0.69) PPARGPPARARXRARARGFFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1089 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4731202-A1 METHODS FOR MEASURING METABOLIC DYSFUNCTION OR RISK OR PRESENCE OF AN AGE-ASSOCIATED DISEASE Loyal Animal Health, Inc. (US) 2026-04-29 EP claimed
US-20260108482-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS ESCIENT PHARMACEUTICALS INC (US) 2026-04-23 US claimed
EP-4725479-A1 PPAR AGONISTS FOR TREATMENT OF DISEASES ASSOCIATED WITH AATD Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2026-04-15 EP claimed
US-20250360215-A1 PHARMACEUTICAL COMBINATIONS AND METHODS FOR PREVENTING OR TREATING NEURODEGENERATIVE DISEASES YUH CHIOU HWA (US) 2025-11-27 US claimed
US-20250332101-A1 Composition CORDEIRO MARIA FRANCESCA (GB) 2025-10-30 US claimed
EP-4640701-A2 GLUCAGON LIKE PEPTIDE 1 (GLP-1) FUSION PEPTIDE COUPLED CYCLIC PEPTIDE TYROSINE TYROSINE CONJUGATES AND USES THEREOF Janssen Sciences Ireland Unlimited Company (IE) 2025-10-29 EP claimed
US-20250281507-A1 METHODS OF TREATING NEPHROTIC SYNDROME THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN’S HOSPITAL 2025-09-11 US claimed
US-20250262209-A1 TREATMENT OF GASTROINTESTINAL DISEASES ACLIPSE TWO INC. 2025-08-21 US claimed
US-20250221962-A1 FABP4 AS A THERAPEUTIC TARGET IN SKIN DISEASES TICURE LTD (IL) 2025-07-10 US claimed
WO-2025136060-A1 CULTURE MEDIUM COMPOSITION FOR TRANSDIFFERENTIATION OF MUSCLE STEM CELLS INTO ADIPOCYTES, AND METHOD FOR PRODUCING CULTURED MEAT BY USING SAME 한화솔루션 주식회사 2025-06-26 WO claimed
CN-114630681-A Treatment of liver diseases or disorders comprising ACTRII receptor antagonists 诺华股份有限公司 2022-06-14 CN claimed
US-20220170034-A1 IMPROVED HOMOLOGY DEPENDENT REPAIR GENOME EDITING INARI AGRICULTURE TECHNOLOGY, INC. 2022-06-02 US claimed
EP-3999103-A1 IMPROVED HOMOLOGY DEPENDENT REPAIR GENOME EDITING Inari Agriculture, Inc. (US) 2022-05-25 EP claimed
EP-3988123-A1 ANTIBODY-COUPLED CYCLIC PEPTIDE TYROSINE TYROSINE COMPOUNDS AS MODULATORS OF NEUROPEPTIDE Y RECEPTORS Janssen Pharmaceutica NV (BE) 2022-04-27 EP claimed
WO-2022081350-A2 METHODS FOR IDENTIFICATION, STRATIFICATION, AND TREATMENT OF CNS DISEASES DUKE UNIVERSITY (US) 2022-04-21 WO claimed
CN-114340632-A Pharmaceutical composition for treating or preventing nonalcoholic steatohepatitis (NASH) 赛特瑞恩股份有限公司 2022-04-12 CN claimed
US-20220096435-A1 FABP4 AS A THERAPEUTIC TARGET IN SKIN DISEASES TICURE LTD. (IL) 2022-03-31 US claimed
WO-2022029334-A1 COMBINATION THERAPIES FOR TREATING CORONAVIRUS INFECTION GBIOTECH S.À.R.L. (CH) 2022-02-10 WO claimed
WO-2022020967-A1 USE OF WNT/BETA-CATENIN PATHWAY INHIBITORS TO BLOCK REPLICATION OF SARS-COV-2 AND OTHER PATHOGENIC VIRUSES THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2022-02-03 WO claimed
US-11229624-B2 FABP4 as a therapeutic target in skin diseases TICURE LTD. (IL) 2022-01-25 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250281507-A1 METHODS OF TREATING NEPHROTIC SYNDROME PPARA, PPARG, PPARD PPARG 2/4885PPARA 1/4885RXRA 60/4885
US-20220096435-A1 FABP4 AS A THERAPEUTIC TARGET IN SKIN DISEASES FABP4, FABP2, FABP1 PPARG 46/4885PPARA 50/4885RXRA 70/4885
US-20260108482-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS MRGPRX4, MRGPRX1, MRGPRX2 PPARG 467/4885PPARA 1336/4885RXRA 159/4885
US-20250262209-A1 TREATMENT OF GASTROINTESTINAL DISEASES FABP6, SLC10A2, FABP2 PPARG 17/4885PPARA 40/4885RXRA 275/4885
US-20250221962-A1 FABP4 AS A THERAPEUTIC TARGET IN SKIN DISEASES FABP4, FABP2, FABP1 PPARG 46/4885PPARA 50/4885RXRA 70/4885
US-11229624-B2 FABP4 as a therapeutic target in skin diseases FABP4, FABP2, FABP1 PPARG 46/4885PPARA 50/4885RXRA 70/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.