Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 7/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.50 |
| ▸ | RAD52 | P43351 | 2/20 | 0.50 |
| ▸ | APAF1 | O14727 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.45 |
| ▸ | LSS | P48449 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5080902 | 1.00 | DNM1 (0.52) | DNM1HSP90AA1RAD52APAF1HTT | |
| SCHEMBL4596200 | 0.98 | APAF1 (0.52) | DNM1HSP90AA1RAD52APAF1HTT | |
| SCHEMBL5884703 | 0.98 | APAF1 (0.52) | DNM1HSP90AA1RAD52APAF1HTT | |
| Bromide SCHEMBL10492627 | 0.95 | DNM1 (0.52) | DNM1HSP90AA1RAD52APAF1HTT | |
| SCHEMBL4595049 | 0.88 | TSHR (0.43) | DNM1HSP90AA1RAD52APAF1HTT | |
| Hydrochloric Acid SCHEMBL4660185 | 0.84 | HTT (0.59) | DNM1HSP90AA1RAD52HTTSMN1; SMN2 | |
| Sulfuric Acid SCHEMBL5078787 | 0.83 | LSS (0.39) | DNM1HSP90AA1RAD52APAF1HTT | |
| Water SCHEMBL7054099 | 0.83 | DNM1 (0.65) | DNM1HSP90AA1RAD52APAF1HTT | |
| Hydrochloric Acid SCHEMBL10573186 | 0.83 | DNM1 (0.65) | DNM1HTTSLC22A1SMN1; SMN2KMT2A | |
| Hydrochloric Acid SCHEMBL10570907 | 0.83 | DNM1 (0.48) | DNM1HSP90AA1RAD52APAF1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7015185-B2 | Ammonium nitriles and the use thereof as hydrophobic bleaching activators | CLARIANT GMBH (DE) | 2006-03-21 | — | — | US | disclosed |
| US-20040266644-A1 | Ammonium nitriles and the use thereof as hydrophobic bleaching activators | CLARIANT PRODUKTE (DEUTSCHLAND) GMBH (DE) | 2004-12-30 | — | — | US | disclosed |