Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 6/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.34 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.34 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | BLM | P54132 | 2/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7866907 | 0.89 | HRH4 (0.35) | SLC7A5CYP3A4CYP1A2LMNABLM | |
| Cysteine SCHEMBL2769343 | 0.87 | PTGS1 (0.42) | SLC7A5CYP3A4GRIA2GRIA4GRIA1 | |
| Phenylalanine SCHEMBL1701460 | 0.84 | SLC7A5 (0.54) | SLC7A5CYP1A2KDM4ELMNAMAPT | |
| SCHEMBL9717841 | 0.75 | CYP1A2 (0.43) | SLC7A5CYP3A4GRIK1GRIA2GRIA4 | |
| SCHEMBL9717852 | 0.75 | CYP1A2 (0.43) | SLC7A5CYP3A4GRIK1GRIA2GRIA4 | |
| SCHEMBL11039378 | 0.74 | CASR (0.32) | BLMNPSR1 | |
| SCHEMBL31370049 | 0.73 | CYP1A2 (0.46) | SLC7A5CYP3A4GRIK1GRIA2GRIA4 | |
| SCHEMBL25354296 | 0.72 | CYP1A2 (0.43) | SLC7A5CYP3A4GRIK1GRIA2GRIA4 | |
| SCHEMBL25354300 | 0.72 | CYP1A2 (0.43) | SLC7A5CYP3A4GRIK1GRIA2GRIA4 | |
| SCHEMBL25354020 | 0.71 | SLC7A5 (0.44) | SLC7A5CYP3A4GRIA2GRIA4GRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7029888-B2 | Modified synthetases to produce penicillins and cephalosporins under the control of bicarbonate | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2006-04-18 | — | — | US | disclosed |
| US-7029888-B2 | Modified synthetases to produce penicillins and cephalosporins under the control of bicarbonate | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2006-04-18 | — | — | US | disclosed |
| US-20020127633-A1 | Modified synthetases to produce penicillins and cephalosporins under the control of bicarbonate | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY (US) | 2002-09-12 | — | — | US | disclosed |
| US-20020127633-A1 | Modified synthetases to produce penicillins and cephalosporins under the control of bicarbonate | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY (US) | 2002-09-12 | — | — | US | disclosed |
| US-6284483-B1 | ACTIVATION OF MUTANT ISOPENICILLIN N SYNTHETASE TO CONVERT (A-AMINOADIPYL)-L-CYSTEINE-D-VALINE TO ISOPENICILLIN N; ISOLATING PENICILLIN G OR V | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY | 2001-09-04 | — | — | US | disclosed |
| US-6284483-B1 | ACTIVATION OF MUTANT ISOPENICILLIN N SYNTHETASE TO CONVERT (A-AMINOADIPYL)-L-CYSTEINE-D-VALINE TO ISOPENICILLIN N; ISOLATING PENICILLIN G OR V | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY | 2001-09-04 | — | — | US | disclosed |