SCHEMBL5885407

SCHEMBL5885407

ICc1ccc(Cc2ccc(CI)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.47
CYP3A4 P08684 4/20 0.47
TSHR P16473 3/20 0.47
TDP1 Q9NUW8 2/20 0.47
ESR1 P03372 1/20 0.47
ESR2 Q92731 1/20 0.47
CALM1 P0DP23 1/20 0.44
MAPK1 P28482 1/20 0.41
HPGD P15428 3/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
TP53 P04637 1/20 0.38
CYP2C9 P11712 1/20 0.38
ALOX15 P16050 1/20 0.38
HSD17B10 Q99714 1/20 0.38
TASP1 Q9H6P5 1/20 0.38
KMT2A Q03164 1/20 0.38
ADRA2A P08913 1/20 0.36
ADRA2B P18089 1/20 0.36
ADRA2C P18825 1/20 0.36
CA1 P00915 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL649682 0.89 ALDH1A1 (0.37) ALDH1A1CYP3A4TSHRTDP1ESR1
SCHEMBL19309114 0.86 IDO1 (0.46) ALDH1A1CYP3A4TSHRTDP1ESR1
SCHEMBL16853360 0.79 GFER (0.47) ALDH1A1ESR1ESR2HPGDALOX15
SCHEMBL679947 0.79 HRH3 (0.47) ALDH1A1CYP3A4TSHRTDP1ESR1
SCHEMBL284077 0.76
SCHEMBL10621952 0.74 CYP2A6 (0.46) ALDH1A1HPGDSMN1; SMN2HSD17B10KMT2A
SCHEMBL17123634 0.74 KDM4E (0.54) CYP3A4KDM4E
SCHEMBL21081404 0.74 APP (0.47) ALDH1A1CYP3A4TSHRHPGDSMN1; SMN2
SCHEMBL2666167 0.73 TP53 (0.50) ALDH1A1TSHRTDP1MAPK1SMN1; SMN2
SCHEMBL2724941 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7030171-B2 Process for producing vinyl polymer having functional group at end and vinyl polymer having functional group at end SEKISUI CHEMICAL CO., LTD. (JP) 2006-04-18 US disclosed
US-20040092619-A1 Process for producing vinyl polymer having functional group at end and vinyl polymer having functional group at end WAKIYA TAKESHI (JP) 2004-05-13 US disclosed
US-6693142-B1 POLYMERIZATION REACTION OF VINYL MONOMERS IN PRESENCE OF HALOGEN COMPOUND AND SUBSTITUTING WITH SUCH AS HYDROXYL, AMINO, VINYL OR SILYL GROUPS SEKISUI CHEMICAL CO., LTD. (JP) 2004-02-17 US disclosed
EP-1243599-A1 PROCESS FOR PRODUCING VINYL POLYMER HAVING FUNCTIONAL GROUP AT END AND VINYL POLYMER HAVING FUNCTIONAL GROUP AT END SEKISUI CHEMICAL CO., LTD. (JP) 2002-09-25 EP disclosed