Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 3/20 | 0.55 |
| ▸ | CA2 | P00918 | 3/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5885636 | 0.88 | LOXL2 (0.56) | LOXL2CA1CA2CA12CA7 | |
| SCHEMBL6147449 | 0.83 | CA12 (0.61) | CA1CA2CA12CA7CA9 | |
| SCHEMBL2607023 | 0.81 | LOXL2 (0.66) | LOXL2CA1CA2CA12CA7 | |
| SCHEMBL6665979 | 0.81 | LOXL2 (0.66) | LOXL2CA1CA2CA12CA7 | |
| SCHEMBL12295081 | 0.78 | LOXL2 (0.61) | LOXL2CA1CA2CA12CA7 | |
| SCHEMBL1520636 | 0.78 | LOXL2 (0.67) | LOXL2CA1CA2CA12CA7 | |
| SCHEMBL13067590 | 0.78 | LOXL2 (0.61) | LOXL2CA1CA2CA12CA7 | |
| SCHEMBL3623300 | 0.78 | LOXL2 (0.61) | LOXL2CA1CA2CA12CA7 | |
| SCHEMBL8873235 | 0.77 | LOXL2 (0.66) | LOXL2CA1CA2CA12CA7 | |
| SCHEMBL131711 | 0.77 | LOXL2 (0.70) | LOXL2CA1CA2CA12CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060825-B2 | Process for synthesizing 6-quinazolinyl-ethyl-benzoyl and related antifolates | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2006-06-13 | — | — | US | disclosed |
| US-20050020833-A1 | Process for synthesizing antifolates | BIONUMERIK PHARMACEUTICALS, INC. | 2005-01-27 | — | — | US | disclosed |
| US-5294621-A | Thieno tetrahydropyridines useful as class III antiarrhythmic agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020833-A1 | Process for synthesizing antifolates | DHFR, FDPS, FOLR1 | LOXL2 3462/4885CA1 2509/4885CA2 3822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.