Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | APAF1 | O14727 | 1/20 | 0.49 |
| ▸ | GRK2 | P25098 | 1/20 | 0.49 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.49 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | BAD | Q92934 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.39 |
| ▸ | NT5E | P21589 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22534057 | 0.85 | MIF (0.41) | RAB9ACYP3A4CYP1A2CYP2C9PRKAG1 | |
| SCHEMBL18114343 | 0.85 | MIF (0.41) | RAB9ACYP3A4CYP1A2CYP2C9PRKAG1 | |
| SCHEMBL14328250 | 0.84 | RAB9A (0.39) | RAB9ANPC1PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL9542642 | 0.84 | RAB9A (0.39) | RAB9ANPC1PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL4505849 | 0.83 | L3MBTL1 (0.43) | POLBRAB9ACYP2C19CYP1A2NPC1 | |
| Hydrochloric Acid SCHEMBL22534094 | 0.83 | MIF (0.40) | RAB9APRKAG1PRKAA2PRKAB1 | |
| SCHEMBL4516734 | 0.83 | APAF1 (0.33) | POLBAPAF1GRK2APOBEC3GPRKAG1 | |
| Hydrochloric Acid SCHEMBL22534093 | 0.83 | MIF (0.40) | RAB9APRKAG1PRKAA2PRKAB1 | |
| SCHEMBL4505854 | 0.83 | L3MBTL1 (0.43) | POLBRAB9ACYP2C19CYP1A2NPC1 | |
| SCHEMBL4516730 | 0.83 | APAF1 (0.33) | POLBAPAF1GRK2APOBEC3GPRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6995182-B2 | 1-sulfonyl pyrrolidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-02-07 | — | — | US | disclosed |
| EP-1299383-B1 | SULFONYL-PYRROLIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | HOFFMANN LA ROCHE (CH) | 2005-01-12 | — | — | EP | disclosed |
| US-20030212066-A1 | 1-Sulfonyl pyrrolidine derivatives | MUTEL VINCENT (FR) | 2003-11-13 | — | — | US | disclosed |
| US-6589978-B2 | Therapy for nervous system disorders | HOFFMAN-LA ROCHE INC. | 2003-07-08 | — | — | US | disclosed |
| EP-1299383-A1 | SULFONYL-PYRROLIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-09 | — | — | EP | disclosed |
| US-20020019424-A1 | 1-sulfonyl pyrrolidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-14 | — | — | US | disclosed |
| WO-2002002554-A1 | SULFONYL-PYRROLIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212066-A1 | 1-Sulfonyl pyrrolidine derivatives | GRM1, GRM2, GRIN1 | POLB 4277/4885APAF1 2349/4885GRK2 64/4885 |
| US-20020019424-A1 | 1-sulfonyl pyrrolidine derivatives | GRM1, GRM2, GRIN1 | POLB 4277/4885APAF1 2349/4885GRK2 64/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.