Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 11/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 6/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 6/20 | 0.62 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5654971 | 0.88 | PTGIR (0.70) | PTGIRADRA2AADRA2BADRA2CGPR65 | |
| SCHEMBL5656120 | 0.87 | ADRA2A (0.55) | PTGIRADRA2AADRA2BADRA2CGPR65 | |
| SCHEMBL5658201 | 0.85 | PTGIR (0.65) | PTGIRADRA2AADRA2BADRA2CGPR65 | |
| SCHEMBL5656473 | 0.81 | PTGIR (0.71) | PTGIRADRA2AADRA2BADRA2CGPR65 | |
| SCHEMBL4686704 | 0.79 | PTGIR (1.00) | PTGIRADRA2AADRA2BADRA2CGPR65 | |
| SCHEMBL13017285 | 0.79 | ADRA2A (1.00) | PTGIRADRA2AADRA2BADRA2C | |
| SCHEMBL5655170 | 0.78 | PTGIR (0.67) | PTGIRADRA2AADRA2BADRA2CGPR65 | |
| SCHEMBL6158355 | 0.78 | PTGIR (0.74) | PTGIRADRA2AADRA2BADRA2C | |
| SCHEMBL5659732 | 0.78 | PTGIR (0.70) | PTGIRADRA2AADRA2BADRA2CGPR65 | |
| SCHEMBL6158402 | 0.76 | PTGIR (0.63) | PTGIRADRA2AADRA2BADRA2CGPR65 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279498-B2 | Substituted aryl amides as IP antagonists | ROCHE PALO ALTO LLC (US) | 2007-10-09 | — | — | US | disclosed |
| US-7279498-B2 | Substituted aryl amides as IP antagonists | ROCHE PALO ALTO LLC (US) | 2007-10-09 | — | — | US | disclosed |
| US-6998414-B2 | Substituted arylamides as IP antagonists | ROCHE PALO ALTO LLC (US) | 2006-02-14 | — | — | US | disclosed |