Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 8/20 | 0.70 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.68 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.68 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4689110 | 0.85 | PTGIR (0.72) | PTGIRADRA2AADRA2BADRA2CSMN1; SMN2 | |
| SCHEMBL4686704 | 0.83 | PTGIR (1.00) | PTGIRADRA2AADRA2BADRA2CGPR65 | |
| SCHEMBL13017285 | 0.83 | ADRA2A (1.00) | PTGIRADRA2AADRA2BADRA2C | |
| SCHEMBL5656473 | 0.80 | PTGIR (0.71) | PTGIRADRA2AADRA2BADRA2CSMN1; SMN2 | |
| SCHEMBL30034264 | 0.80 | SMN1; SMN2 (0.88) | SMN1; SMN2LMNAMAPTALDH1A1RAB9A | |
| SCHEMBL5654971 | 0.79 | PTGIR (0.70) | PTGIRADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL5805033 | 0.79 | PTGIR (1.00) | PTGIRADRA2AADRA2BADRA2C | |
| SCHEMBL5803970 | 0.79 | PTGIR (1.00) | PTGIRADRA2AADRA2BADRA2CGPR65 | |
| SCHEMBL5886015 | 0.78 | PTGIR (0.69) | PTGIRADRA2AADRA2BADRA2CGPR65 | |
| SCHEMBL5658201 | 0.78 | PTGIR (0.65) | PTGIRADRA2AADRA2BADRA2CSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279498-B2 | Substituted aryl amides as IP antagonists | ROCHE PALO ALTO LLC (US) | 2007-10-09 | — | — | US | disclosed |
| US-7279498-B2 | Substituted aryl amides as IP antagonists | ROCHE PALO ALTO LLC (US) | 2007-10-09 | — | — | US | disclosed |
| US-7279498-B2 | Substituted aryl amides as IP antagonists | ROCHE PALO ALTO LLC (US) | 2007-10-09 | — | — | US | disclosed |
| US-6998414-B2 | Substituted arylamides as IP antagonists | ROCHE PALO ALTO LLC (US) | 2006-02-14 | — | — | US | disclosed |
| US-20060004075-A1 | Substituted aryl amides as IP antagonists | ROCHE PALO ALTO LLC | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004075-A1 | Substituted aryl amides as IP antagonists | INSR, INSRR, GIPR | PTGIR 44/4885ADRA2A 90/4885ADRA2B 82/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.