Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 10/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | F12 | P00748 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5658518 | 0.87 | NSD2 (0.58) | PTGIRADRA2AADRA2BADRA2CALDH1A1 | |
| SCHEMBL5654971 | 0.86 | PTGIR (0.70) | PTGIRADRA2AADRA2BADRA2CGPR65 | |
| SCHEMBL5886015 | 0.85 | PTGIR (0.69) | PTGIRADRA2AADRA2BADRA2CGPR65 | |
| SCHEMBL5656473 | 0.79 | PTGIR (0.71) | PTGIRADRA2AADRA2BADRA2CALDH1A1 | |
| SCHEMBL5659732 | 0.78 | PTGIR (0.70) | PTGIRADRA2AADRA2BADRA2CALDH1A1 | |
| SCHEMBL4686704 | 0.77 | PTGIR (1.00) | PTGIRADRA2AADRA2BADRA2CGPR65 | |
| SCHEMBL13017285 | 0.77 | ADRA2A (1.00) | PTGIRADRA2AADRA2BADRA2C | |
| SCHEMBL5655170 | 0.76 | PTGIR (0.67) | PTGIRADRA2AADRA2BADRA2CALDH1A1 | |
| SCHEMBL6158355 | 0.76 | PTGIR (0.74) | PTGIRADRA2AADRA2BADRA2CALDH1A1 | |
| Hydrochloric Acid SCHEMBL4689110 | 0.73 | PTGIR (0.72) | PTGIRADRA2AADRA2BADRA2CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279498-B2 | Substituted aryl amides as IP antagonists | ROCHE PALO ALTO LLC (US) | 2007-10-09 | — | — | US | disclosed |
| US-7279498-B2 | Substituted aryl amides as IP antagonists | ROCHE PALO ALTO LLC (US) | 2007-10-09 | — | — | US | disclosed |
| US-7279498-B2 | Substituted aryl amides as IP antagonists | ROCHE PALO ALTO LLC (US) | 2007-10-09 | — | — | US | disclosed |
| US-6998414-B2 | Substituted arylamides as IP antagonists | ROCHE PALO ALTO LLC (US) | 2006-02-14 | — | — | US | disclosed |
| US-20060004075-A1 | Substituted aryl amides as IP antagonists | ROCHE PALO ALTO LLC | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004075-A1 | Substituted aryl amides as IP antagonists | INSR, INSRR, GIPR | PTGIR 44/4885ADRA2A 90/4885ADRA2B 82/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.