Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 3/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.36 |
| ▸ | FNTA | P49354 | 10/20 | 0.35 |
| ▸ | FNTB | P49356 | 10/20 | 0.35 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5886640 | 1.00 | CTSC (0.40) | CTSCMETAP2METAP1DPP4DPP8 | |
| SCHEMBL9352805 | 0.84 | CTSC (0.41) | CTSCMETAP2METAP1DPP4DPP8 | |
| SCHEMBL9352804 | 0.84 | CTSC (0.41) | CTSCMETAP2METAP1DPP4DPP8 | |
| SCHEMBL14065663 | 0.80 | METAP2 (0.44) | CTSCMETAP2METAP1DPP4DPP8 | |
| SCHEMBL14065664 | 0.80 | METAP2 (0.44) | CTSCMETAP2METAP1DPP4DPP8 | |
| SCHEMBL28081126 | 0.79 | DPP4 (0.58) | CTSCDPP4DPP8DPP9LMNA | |
| SCHEMBL11482808 | 0.79 | SLC15A1 (0.54) | METAP1DPP4DPP8DPP9 | |
| SCHEMBL6535678 | 0.79 | CTSC (0.43) | CTSCMETAP2METAP1DPP4DPP8 | |
| SCHEMBL6535676 | 0.79 | CTSC (0.43) | CTSCMETAP2METAP1DPP4DPP8 | |
| SCHEMBL13444876 | 0.78 | METAP2 (0.43) | CTSCMETAP2METAP1DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144576-B1 | Modified pertussis toxin | AMGEN, INC. (US) | 2006-12-05 | — | — | US | claimed |
| EP-0306318-B2 | Recombinant DNA-derived bordetella toxin subunit analogs | AMGEN INC (US) | 2004-04-28 | — | — | EP | claimed |
| JP-2918895-B2 | — | — | 1999-07-12 | — | — | JP | claimed |
| EP-0306318-B1 | Recombinant DNA-derived bordetella toxin subunit analogs | AMGEN INC (US) | 1995-07-26 | — | — | EP | claimed |
| EP-0629696-A1 | Recombinant DNA-derived bordetella toxin subunit analogs | AMGEN INC. (US) | 1994-12-21 | — | — | EP | claimed |
| WO-1989001976-A1 | RECOMBINANT DNA-DERIVED BORDETELLA TOXIN SUBUNIT ANALOGS | AMGEN INC. (US) | 1989-03-09 | — | — | WO | claimed |
| EP-0306318-A1 | Recombinant DNA-derived bordetella toxin subunit analogs | AMGEN INC. (US) | 1989-03-08 | — | — | EP | claimed |
| US-7144576-B1 | Modified pertussis toxin | AMGEN, INC. (US) | 2006-12-05 | — | — | US | disclosed |
| EP-0306318-B2 | Recombinant DNA-derived bordetella toxin subunit analogs | AMGEN INC (US) | 2004-04-28 | — | — | EP | disclosed |
| US-5773600-A | GENETIC ENGINEERING | AMGEN INC. (US) | 1998-06-30 | — | — | US | disclosed |
| EP-0306318-B1 | Recombinant DNA-derived bordetella toxin subunit analogs | AMGEN INC (US) | 1995-07-26 | — | — | EP | disclosed |
| EP-0629696-A1 | Recombinant DNA-derived bordetella toxin subunit analogs | AMGEN INC. (US) | 1994-12-21 | — | — | EP | disclosed |
| WO-1989001976-A1 | RECOMBINANT DNA-DERIVED BORDETELLA TOXIN SUBUNIT ANALOGS | AMGEN INC. (US) | 1989-03-09 | — | — | WO | disclosed |
| EP-0306318-A1 | Recombinant DNA-derived bordetella toxin subunit analogs | AMGEN INC. (US) | 1989-03-08 | — | — | EP | disclosed |