Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | KLK1 | P06870 | 1/20 | 0.40 |
| ▸ | KHK | P50053 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 3/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | AKT2 | P31751 | 2/20 | 0.39 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5887048 | 0.96 | MAPT (0.42) | HTTMAPTKLKB1KLK1KHK | |
| SCHEMBL5887505 | 0.93 | MGAM (0.41) | HTTMAPTKLKB1KLK1KHK | |
| SCHEMBL5887563 | 0.92 | EPHX2 (0.42) | HTTMAPTNAMPTHDAC3HDAC4 | |
| SCHEMBL5887646 | 0.92 | MAPK1 (0.40) | HTTMAPTKLKB1KLK1NAMPT | |
| SCHEMBL5887334 | 0.89 | ALDH1A1 (0.44) | HTTMAPTNAMPTGAAMEN1 | |
| SCHEMBL5887675 | 0.89 | SLC6A7 (0.44) | MAPTKLKB1MEN1KMT2AALDH1A1 | |
| SCHEMBL5886700 | 0.86 | MGLL (0.42) | MAPTKLKB1MEN1KMT2AALDH1A1 | |
| SCHEMBL5887572 | 0.85 | MAPT (0.39) | HTTMAPTKLKB1KHKMMP12 | |
| SCHEMBL5886889 | 0.85 | MAPK10 (0.45) | NAMPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5886777 | 0.85 | NAMPT (0.46) | HTTMAPTNAMPTHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7019002-B2 | Substituted on 8th position with benzoic acid, ester or amide groups; anticancer agents | PHARMACIA & UPJOHN, S.P.A. (IT) | 2006-03-28 | — | — | US | disclosed |