Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | CCR6 | P51684 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5887353 | 0.91 | MEN1 (0.35) | KMT2AMEN1RAB9ANPC1TP53 | |
| SCHEMBL5887155 | 0.90 | NOTUM (0.36) | NPC1MAPK10SMN1; SMN2 | |
| SCHEMBL5887105 | 0.87 | ESR2 (0.35) | NPC1MAPK10TP53SMN1; SMN2POLB | |
| SCHEMBL5887288 | 0.87 | ALDH1A3 (0.41) | CNR1L3MBTL1SMN1; SMN2ALDH1A1GPBAR1 | |
| SCHEMBL5887143 | 0.85 | PTGS2 (0.35) | KMT2AMEN1RAB9AALDH1A1HPGD | |
| SCHEMBL6416879 | 0.85 | HPGD (0.32) | KMT2AMEN1TP53HPGD | |
| SCHEMBL6047606 | 0.83 | NR1I3 (0.39) | RAB9ANPC1MAPK10TP53SMN1; SMN2 | |
| SCHEMBL5887285 | 0.81 | ALKBH3 (0.44) | KMT2AMEN1RAB9ANPC1TDP1 | |
| SCHEMBL5887667 | 0.81 | NPC1 (0.39) | KMT2AMEN1CNR1RAB9ANPC1 | |
| SCHEMBL6047579 | 0.80 | GRIA1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037931-B2 | Corticotropin releasing factor moderator; analgesics; drug abruse, drug dependency; schizophrenia | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-02 | — | — | US | claimed |