Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5887546 | 0.87 | DYRK1A (0.44) | GAACYP3A4NOTUMCYP1A2CYP2D6 | |
| SCHEMBL4804654 | 0.78 | ACHE (0.39) | KDM4ETDP1TP53ALDH1A1TSHR | |
| SCHEMBL6408167 | 0.77 | MAPT (0.33) | MAPTKDM4ETP53ALDH1A1TSHR | |
| SCHEMBL6047594 | 0.77 | NAAA (0.40) | MAPTKDM4ERXRARXRBTHRB | |
| SCHEMBL4012746 | 0.74 | NOTUM (0.36) | MAPTKDM4ETP53NOTUMALDH1A1 | |
| SCHEMBL6047605 | 0.74 | CYP1A1 (0.44) | THRBCYP3A4BRD4ALDH1A1LMNA | |
| SCHEMBL5887031 | 0.73 | CDC25A (0.44) | GAATDP1RAB9ANPC1DHFR | |
| SCHEMBL29426410 | 0.73 | RXRA (0.66) | MAPTGAAKDM4ERXRARXRB | |
| SCHEMBL9260410 | 0.73 | RXRA (0.66) | MAPTGAAKDM4ERXRARXRB | |
| SCHEMBL29012837 | 0.71 | RXRA (0.64) | MAPTGAAKDM4ERXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037931-B2 | Corticotropin releasing factor moderator; analgesics; drug abruse, drug dependency; schizophrenia | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-02 | — | — | US | claimed |