Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1134975 | 1.00 | ELANE (0.46) | ELANESIRT3KMT2AMEN1POLB | |
| SCHEMBL5887434 | 1.00 | ELANE (0.46) | ELANESIRT3KMT2AMEN1POLB | |
| SCHEMBL28495663 | 0.89 | ELANE (0.49) | ELANEKMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL7729786 | 0.87 | ELANE (0.47) | ELANEKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL7732985 | 0.86 | ELANE (0.46) | ELANEKMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL5964086 | 0.86 | ELANE (0.49) | ELANEKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7778743 | 0.85 | ELANE (0.45) | ELANEKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL7772609 | 0.84 | ELANE (0.47) | ELANEKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5963742 | 0.84 | ELANE (0.44) | ELANEALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL5963529 | 0.84 | ELANE (0.44) | ELANEKMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-7070057-A | — | — | None | — | — | JP | disclosed |
| US-7074945-B2 | Metal alkoxide taxane derivatives | FLORIDA STATE UNIVERSITY (US) | 2006-07-11 | — | — | US | disclosed |
| US-20040073048-A1 | Perparation of substituted isoserine esters using metal alkoxides and beta-lactams | FLORIDA STATE UNIVERSITY | 2004-04-15 | — | — | US | disclosed |
| US-6683196-B2 | REACTING RACEMIC BETA-LACTAM WITH LITHIUM- 7-PROTECTED BACCATIN III- COMPLEX TO FORM 3'DESPHENYL-3'-(1-NAPTHYL)TAXOL; ANTITUMOR AGENTS | FLORIDA STATE UNIVERSITY | 2004-01-27 | — | — | US | disclosed |
| EP-0884314-B1 | Metal alkoxides | UNIV FLORIDA STATE (US) | 2004-01-21 | — | — | EP | disclosed |
| CN-1428337-A | Method for synthesizing taxol C-13 side chain precursor | YAN JIAQI (CN) | 2003-07-09 | — | — | CN | disclosed |
| US-20030120096-A1 | Reacting racemic beta-lactam with lithium- 7-protected baccatin III- complex to form 3'desphenyl-3'-(1-napthyl)taxol; antitumor agents | FLORIDA STATE UNIVERSITY | 2003-06-26 | — | — | US | disclosed |
| US-6562962-B2 | Reacting metal alkoxides and beta-lactams to form substituted isoserine ester derivatives; antitumor agents; highly diastereoselective eliminating need to separate precursor into enantiomeric forms | FLORIDA STATE UNIVERSITY | 2003-05-13 | — | — | US | disclosed |
| CN-1392145-A | Semi synthetic method for taxol | PEIWOTE BIOLOG GENE ENGINEERIN (CN) | 2003-01-22 | — | — | CN | disclosed |
| US-6479678-B1 | Metal alkoxide taxane and β-lactam compounds | FLORIDA STATE UNIVERSITY | 2002-11-12 | — | — | US | disclosed |
| US-5384399-A | Oxazinone compounds for the preparation of taxol | FLORIDA STATE UNIVERSITY (US) | 1995-01-24 | — | — | US | disclosed |
| US-5336785-A | Reacting a beta-lactam with an alcohol to form a taxol intermediate | FLORIDA STATE UNIVERSITY (US) | 1994-08-09 | — | — | US | disclosed |
| US-5274124-A | Metal alkoxides | FLORIDA STATE UNIVERSITY (US) | 1993-12-28 | — | — | US | disclosed |
| US-5229526-A | METAL ALKOXIDES | FLORIDA STATE UNIVERSITY (US) | 1993-07-20 | — | — | US | disclosed |
| WO-1993006079-A1 | PREPARATION OF SUBSTITUTED ISOSERINE ESTERS USING METAL ALKOXIDES AND β-LACTAMS | FLORIDA STATE UNIVERSITY (US) | 1993-04-01 | — | — | WO | disclosed |
| US-5175315-A | Reacting with alcohol in presence of altivating agent | FLORIDA STATE UNIVERSITY (US) | 1992-12-29 | — | — | US | disclosed |
| US-5136060-A | Reacting with alcohol | FLORIDA STATE UNIVERSITY (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0428376-A1 | Method for preparation of taxol using an oxazinone | FLORIDA STATE UNIVERSITY (US) | 1991-05-22 | — | — | EP | disclosed |
| US-5015744-A | Esterification of an alcohol with an oxazinone | FLORIDA STATE UNIVERSITY (US) | 1991-05-14 | — | — | US | disclosed |
| EP-0400971-A2 | Method for preparation of taxol | FLORIDA STATE UNIVERSITY (US) | 1990-12-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030120096-A1 | Reacting racemic beta-lactam with lithium- 7-protected baccatin III- complex to form 3'desphenyl-3'-(1-napthyl)taxol; antitumor agents | CIAPIN1, NCSTN, AP3S1 | ELANE 3196/4885SIRT3 649/4885KMT2A 4642/4885 |
| US-20040073048-A1 | Perparation of substituted isoserine esters using metal alkoxides and beta-lactams | AGPS, PSPH, PTMS | ELANE 2625/4885SIRT3 2565/4885KMT2A 3879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.