Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | TTK | P33981 | 3/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 6/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 6/20 | 0.36 |
| ▸ | ST14 | Q9Y5Y6 | 6/20 | 0.36 |
| ▸ | F2 | P00734 | 4/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5887013 | 0.88 | TTK (0.40) | MAPK8TTKSMYD3MAPTTHRB | |
| SCHEMBL5887244 | 0.87 | MAPK14 (0.44) | MAPK8TTKTHRBSMN1; SMN2ALDH1A1 | |
| SCHEMBL5887098 | 0.87 | PARP10 (0.37) | F2ALDH1A1 | |
| SCHEMBL5886782 | 0.86 | PDE4B (0.44) | MAPK8TTKMAPTTHRBPDE4B | |
| SCHEMBL5887588 | 0.85 | SMN1; SMN2 (0.42) | MAPK8TTKSMYD3MAPTTHRB | |
| SCHEMBL5887357 | 0.85 | MAPK14 (0.47) | MAPK8MAPTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL5886861 | 0.84 | MAPK14 (0.40) | MAPK8MAPTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL5887445 | 0.83 | KMT2A (0.38) | MAPK8TTKMAPTTHRBLMNA | |
| SCHEMBL5886928 | 0.83 | MAPK14 (0.46) | MAPK8LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL5886785 | 0.82 | EPHX2 (0.40) | MAPK8MAPTLMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7019002-B2 | Substituted on 8th position with benzoic acid, ester or amide groups; anticancer agents | PHARMACIA & UPJOHN, S.P.A. (IT) | 2006-03-28 | — | — | US | claimed |
| US-20040009993-A1 | Pyridopyrimidinones derivatives as telomerase inhibitors | PHARMACIA ITALIA S.P.A. | 2004-01-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040009993-A1 | Pyridopyrimidinones derivatives as telomerase inhibitors | TERT, TERF2, TERF2IP | MAPK8 770/4885TTK 681/4885PTK2 1901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.