Sugi Predict

Sugi Predict / Compounds / SCHEMBL5887753

SCHEMBL5887753

SCHEMBL5887753

COC(=O)C(Cc1ccc(F)cc1)C(=O)O

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ LDHA P00338 2/20 0.54
▸ PPARG P37231 5/20 0.53
▸ PPARA Q07869 3/20 0.53
▸ PPARD Q03181 2/20 0.53
▸ PTPRB P23467 1/20 0.51
▸ NOS2 P35228 3/20 0.51
▸ NOS3 P29474 2/20 0.51
▸ NOS1 P29475 2/20 0.51
▸ CA12 O43570 1/20 0.51
▸ CA7 P43166 1/20 0.51
▸ CA9 Q16790 1/20 0.51
▸ CA14 Q9ULX7 1/20 0.51
▸ TSHR P16473 1/20 0.50
▸ MEN1 O00255 1/20 0.48
▸ GAA P10253 1/20 0.48
▸ KMT2A Q03164 1/20 0.48
▸ CPA1 P15085 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5888360 0.93 PTPRB (0.58) LDHAPPARGPPARAPPARDPTPRB
SCHEMBL855971 0.88 NOS2 (0.50) LDHAPPARGPPARAPPARDPTPRB
SCHEMBL3779421 0.85 NOS2 (0.48) LDHAPPARGPPARAPPARDPTPRB
SCHEMBL3989322 0.85 MMP8 (0.55) LDHAPPARGPPARAMEN1KMT2A
SCHEMBL391783 0.84 PPARG (0.61) LDHAPPARGPPARAPPARDPTPRB
SCHEMBL8287672 0.84 PPARG (0.61) LDHAPPARGPPARAPPARDPTPRB
SCHEMBL5888837 0.84 CA12 (0.53) PPARGPPARAPPARDPTPRBNOS2
SCHEMBL8841184 0.83 TSHR (0.48) NOS2NOS3NOS1CA12CA7
SCHEMBL754625 0.83 LDHA (0.57) LDHAPPARGPPARAKMT2ACPA1
SCHEMBL3102934 0.83 LDHA (0.54) LDHAPPARGPPARAPPARDPTPRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11376260-B2 Serine/threonine kinase inhibitors GENENTECH, INC. (US) 2022-07-05 — — US disclosed
US-20210106593-A1 SERINE/THREONINE KINASE INHIBITORS GENENTECH, INC. (US) 2021-04-15 — — US disclosed
US-10842799-B2 Serine/threonine kinase inhibitors GENENTECH, INC. (US) 2020-11-24 — — US disclosed
US-20200078371-A1 SERINE/THREONINE KINASE INHIBITORS GENENTECH, INC. (US) 2020-03-12 — — US disclosed
US-20190192534-A1 SERINE/THREONINE KINASE INHIBITORS GENENTECH, INC. (US) 2019-06-27 — — US disclosed
US-10278975-B2 Serine/threonine kinase inhibitors GENENTECH, INC. (US) 2019-05-07 — — US disclosed
EP-3077401-B1 SERINE/THREONINE KINASE INHIBITORS GENENTECH INC (US) 2018-04-18 — — EP disclosed
US-9867833-B2 Serine/threonine kinase inhibitors GENENTECH, INC. (US) 2018-01-16 — — US disclosed
US-20180000833-A1 SERINE/THREONINE KINASE INHIBITORS GENENTECH, INC. (US) 2018-01-04 — — US disclosed
EP-3077401-A1 SERINE/THREONINE KINASE INHIBITORS Genentech, Inc. (US) 2016-10-12 — — EP disclosed
US-20150182537-A1 SERINE/THREONINE KINASE INHIBITORS GENENTECH, INC. (US) 2015-07-02 — — US disclosed
WO-2015085007-A1 SERINE/THREONINE KINASE INHIBITORS GENENTECH, INC. (US) 2015-06-11 — — WO disclosed
US-7026335-B2 Melanocortin receptor ligands THE PROCTER & GAMBLE CO. (US) 2006-04-11 — — US disclosed
CN-1656070-A Melanocortin receptor ligands PROCTER & GAMBLE (US) 2005-08-17 — — CN disclosed
US-20050171158-A1 Melanocortin receptor ligands EBETINO FRANK H (US) 2005-08-04 — — US disclosed
EP-1499588-A1 MELANOCORTIN RECEPTOR LIGANDS THE PROCTER & GAMBLE COMPANY (US) 2005-01-26 — — EP disclosed
US-20030236230-A1 Melanocortin receptor ligands THE PROCTER & GAMBLE COMPANY 2003-12-25 — — US disclosed
WO-2003093234-A1 MELANOCORTIN RECEPTOR LIGANDS THE PROCTER & GAMBLE COMPANY (US) 2003-11-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11376260-B2 Serine/threonine kinase inhibitors MAP3K1, MAP3K4, MAP4K2 LDHA 3625/4885PPARG 4471/4885PPARA 4545/4885
US-10842799-B2 Serine/threonine kinase inhibitors MAP3K1, MAP3K4, MAP4K2 LDHA 3625/4885PPARG 4471/4885PPARA 4545/4885
US-20150182537-A1 SERINE/THREONINE KINASE INHIBITORS MAP3K1, MAP3K4, MAP4K2 LDHA 3625/4885PPARG 4471/4885PPARA 4545/4885
US-20050171158-A1 Melanocortin receptor ligands MC1R, MC4R, MC5R LDHA 748/4885PPARG 914/4885PPARA 659/4885
US-20180000833-A1 SERINE/THREONINE KINASE INHIBITORS MAP3K1, MAP3K4, MAP4K2 LDHA 3625/4885PPARG 4471/4885PPARA 4545/4885
US-10278975-B2 Serine/threonine kinase inhibitors MAP3K1, MAP3K4, MAP4K2 LDHA 3625/4885PPARG 4471/4885PPARA 4545/4885
US-20190192534-A1 SERINE/THREONINE KINASE INHIBITORS MAP3K1, MAP3K4, MAP4K2 LDHA 3625/4885PPARG 4471/4885PPARA 4545/4885
US-20210106593-A1 SERINE/THREONINE KINASE INHIBITORS MAP3K1, MAP3K4, MAP4K2 LDHA 3625/4885PPARG 4471/4885PPARA 4545/4885
US-20200078371-A1 SERINE/THREONINE KINASE INHIBITORS MAP3K1, MAP3K4, MAP4K2 LDHA 3625/4885PPARG 4471/4885PPARA 4545/4885
US-20030236230-A1 Melanocortin receptor ligands MC1R, MC4R, MC5R LDHA 841/4885PPARG 1081/4885PPARA 700/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.