Zearalenone

Zearalenone

SCHEMBL588840

CC1CCCC(=O)CCC/C=C\c2cc(O)cc(O)c2C(=O)O1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 1.00
LMNA P02545 3/20 1.00
SMN1; SMN2 Q16637 3/20 1.00
CYP3A4 P08684 2/20 1.00
HPGD P15428 2/20 1.00
HSP90AA1 P07900 2/20 1.00
HSP90AB1 P08238 2/20 1.00
ESR2 Q92731 2/20 1.00
GAA P10253 1/20 1.00
ALOX15 P16050 1/20 1.00
TSHR P16473 1/20 1.00
MAPK1 P28482 1/20 1.00
PTK2B Q14289 1/20 1.00
HSD17B10 Q99714 1/20 1.00
CBR1 P16152 1/20 0.76
ESR1 P03372 1/20 0.76
STAT3 P40763 1/20 0.76
NR1I2 O75469 1/20 0.76
MKNK2 Q9HBH9 4/20 0.72
F13A1 P00488 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Zearalenone SCHEMBL588841 1.00 ALDH1A1 (1.00) ALDH1A1LMNASMN1; SMN2CYP3A4HPGD
Zearalenone SCHEMBL588842 1.00 ALDH1A1 (1.00) ALDH1A1LMNASMN1; SMN2CYP3A4HPGD
Zearalenone SCHEMBL29354213 1.00 ALDH1A1 (1.00) ALDH1A1LMNASMN1; SMN2CYP3A4HPGD
Zearalenone SCHEMBL33754 1.00 ALDH1A1 (1.00) ALDH1A1LMNASMN1; SMN2CYP3A4HPGD
Zearalenone SCHEMBL33755 1.00 ALDH1A1 (1.00) ALDH1A1LMNASMN1; SMN2CYP3A4HPGD
Zearalenone SCHEMBL28179514 0.99 ALDH1A1 (0.98) ALDH1A1LMNASMN1; SMN2CYP3A4HPGD
Zearalenone SCHEMBL23827347 0.96 ALDH1A1 (0.92) ALDH1A1LMNASMN1; SMN2CYP3A4HPGD
Zearalenone SCHEMBL28547269 0.96 ALDH1A1 (0.92) ALDH1A1LMNASMN1; SMN2CYP3A4HPGD
SCHEMBL21662430 0.90 ALDH1A1 (0.81) ALDH1A1LMNASMN1; SMN2CYP3A4HPGD
SCHEMBL14201132 0.90 ALDH1A1 (0.81) ALDH1A1LMNASMN1; SMN2CYP3A4HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2417118-B1 A PROCESS FOR MANUFACTURING ZERANOL INTERVET INT BV (NL) 2016-01-27 EP disclosed
EP-2417118-A1 A PROCESS FOR MANUFACTURING ZERANOL Intervet International B.V. (NL) 2012-02-15 EP disclosed
WO-2010115478-A1 A PROCESS FOR MANUFACTURING ZERANOL INTERVET INTERNATIONAL B.V. (NL) 2010-10-14 WO disclosed