Zearalenone — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ADRB3 CYP11B1 DPP4 FGFR1 FGFR2 FGFR3 FGFR4 HRH1 JAK1 JAK2 JAK3 KCNA1 KCNA10 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNB1 KCNB2 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNS1 KCNS2 KCNS3 KCNV1 KCNV2 KDR KIT NA OPRD1 OPRK1 OPRM1 P PDGFRB PIK3CD SCN10A SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A SMO TYK2 pol rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Zearalenone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	KIT known ✓	P10721	5/20	0.55

▸	KDR known ✓	P35968	4/20	0.55

▸	PDGFRB known ✓	P09619	1/20	0.53

▸	ALDH1A1	P00352	3/20	0.92

▸	LMNA	P02545	3/20	0.92

▸	SMN1; SMN2	Q16637	3/20	0.92

▸	CYP3A4	P08684	2/20	0.92

▸	HPGD	P15428	2/20	0.92

▸	HSP90AA1	P07900	2/20	0.92

▸	HSP90AB1	P08238	2/20	0.92

▸	ESR2	Q92731	2/20	0.92

▸	GAA	P10253	1/20	0.92

▸	ALOX15	P16050	1/20	0.92

▸	TSHR	P16473	1/20	0.92

▸	MAPK1	P28482	1/20	0.92

▸	PTK2B	Q14289	1/20	0.92

▸	HSD17B10	Q99714	1/20	0.92

▸	CBR1	P16152	1/20	0.70

▸	ESR1	P03372	1/20	0.70

▸	STAT3	P40763	1/20	0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Zearalenone SCHEMBL588840	0.96	ALDH1A1 (1.00)	ALDH1A1LMNASMN1; SMN2CYP3A4HPGD
Zearalenone SCHEMBL588841	0.96	ALDH1A1 (1.00)	ALDH1A1LMNASMN1; SMN2CYP3A4HPGD
Zearalenone SCHEMBL29354213	0.96	ALDH1A1 (1.00)	ALDH1A1LMNASMN1; SMN2CYP3A4HPGD
Zearalenone SCHEMBL33754	0.96	ALDH1A1 (1.00)	ALDH1A1LMNASMN1; SMN2CYP3A4HPGD
Zearalenone SCHEMBL33755	0.96	ALDH1A1 (1.00)	ALDH1A1LMNASMN1; SMN2CYP3A4HPGD
Zearalenone SCHEMBL588842	0.96	ALDH1A1 (1.00)	ALDH1A1LMNASMN1; SMN2CYP3A4HPGD
Zearalenone SCHEMBL28179514	0.95	ALDH1A1 (0.98)	ALDH1A1LMNASMN1; SMN2CYP3A4HPGD
Zearalenone SCHEMBL23827347	0.92	ALDH1A1 (0.92)	ALDH1A1LMNASMN1; SMN2CYP3A4HPGD
SCHEMBL21662430	0.86	ALDH1A1 (0.81)	ALDH1A1LMNASMN1; SMN2CYP3A4HPGD
SCHEMBL14201132	0.86	ALDH1A1 (0.81)	ALDH1A1LMNASMN1; SMN2CYP3A4HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-112410269-A	Bacillus subtilis and application thereof in degradation of zearalenone	中国科学院天津工业生物技术研究所	2021-02-26	—	—	CN	claimed
CN-117625576-A	Zearalenone degrading enzyme and preparation and application thereof	昆明爱科特生物科技有限公司	2024-03-01	—	—	CN	disclosed
CN-117625576-A	Zearalenone degrading enzyme and preparation and application thereof	昆明爱科特生物科技有限公司	2024-03-01	—	—	CN	disclosed
CN-112410269-B	Bacillus subtilis and application thereof in degradation of zearalenone	中国科学院天津工业生物技术研究所	2021-10-22	—	—	CN	disclosed
CN-112410269-B	Bacillus subtilis and application thereof in degradation of zearalenone	中国科学院天津工业生物技术研究所	2021-10-22	—	—	CN	disclosed
CN-112410269-A	Bacillus subtilis and application thereof in degradation of zearalenone	中国科学院天津工业生物技术研究所	2021-02-26	—	—	CN	disclosed
CN-112410269-A	Bacillus subtilis and application thereof in degradation of zearalenone	中国科学院天津工业生物技术研究所	2021-02-26	—	—	CN	disclosed