Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | CTSS | P25774 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 1/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.50 |
| ▸ | CTSA | P10619 | 3/20 | 0.46 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5888650 | 1.00 | CTSL (0.52) | CTSLCTSSCTSKPSEN1PSEN2 | |
| SCHEMBL5888653 | 1.00 | CTSL (0.52) | CTSLCTSSCTSKPSEN1PSEN2 | |
| SCHEMBL5888232 | 0.84 | CTSL (0.50) | CTSLCTSSCTSKCTSAALDH1A1 | |
| SCHEMBL5888225 | 0.84 | CTSL (0.50) | CTSLCTSSCTSKCTSAALDH1A1 | |
| SCHEMBL5888229 | 0.84 | CTSL (0.50) | CTSLCTSSCTSKCTSAALDH1A1 | |
| SCHEMBL5888631 | 0.83 | CTSL (0.51) | CTSLCTSSCTSKPSEN1PSEN2 | |
| SCHEMBL5888488 | 0.82 | CTSL (0.49) | CTSLCTSSCTSKPSEN1PSEN2 | |
| SCHEMBL5888493 | 0.82 | CTSL (0.49) | CTSLCTSSCTSKPSEN1PSEN2 | |
| SCHEMBL5888518 | 0.81 | METAP2 (0.49) | CTSLCTSSCTSKPSEN1PSEN2 | |
| SCHEMBL5888529 | 0.81 | METAP2 (0.49) | CTSLCTSSCTSKPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7135472-B2 | 3-Heterocyclic benzylamide derivatives as potassium channel openers | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-11-14 | — | — | US | disclosed |