Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.50 |
| ▸ | CTSS | P25774 | 2/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | CTSV | O60911 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | PRCP | P42785 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CTSA | P10619 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5888225 | 1.00 | CTSL (0.50) | CTSLCTSSCTSKOPRK1CTSV | |
| SCHEMBL5888232 | 1.00 | CTSL (0.50) | CTSLCTSSCTSKOPRK1CTSV | |
| SCHEMBL5888653 | 0.84 | CTSL (0.52) | CTSLCTSSCTSKMEN1CTSA | |
| SCHEMBL5888656 | 0.84 | CTSL (0.52) | CTSLCTSSCTSKMEN1CTSA | |
| SCHEMBL5888650 | 0.84 | CTSL (0.52) | CTSLCTSSCTSKMEN1CTSA | |
| SCHEMBL5888153 | 0.81 | PRCP (0.54) | CTSLCTSSCTSKCTSVCTSB | |
| SCHEMBL5888147 | 0.81 | PRCP (0.54) | CTSLCTSSCTSKCTSVCTSB | |
| SCHEMBL5888518 | 0.81 | METAP2 (0.49) | CTSLCTSSCTSKCTSA | |
| SCHEMBL5888529 | 0.81 | METAP2 (0.49) | CTSLCTSSCTSKCTSA | |
| SCHEMBL5888521 | 0.81 | METAP2 (0.49) | CTSLCTSSCTSKCTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7135472-B2 | 3-Heterocyclic benzylamide derivatives as potassium channel openers | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-11-14 | — | — | US | disclosed |