Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 12/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5889282 | 0.95 | EPHX2 (0.56) | EPHX2MEN1KMT2AGRIN2DGRIN3B | |
| SCHEMBL5889279 | 0.82 | EPHX2 (0.53) | EPHX2MEN1KMT2AGRIN2DGRIN3B | |
| SCHEMBL5889272 | 0.77 | ALDH1A1 (0.57) | EPHX2KMT2AALDH1A1MAPTHTT | |
| SCHEMBL5889278 | 0.73 | MEN1 (0.42) | EPHX2MEN1KMT2AGRIN2DGRIN3B | |
| SCHEMBL10957944 | 0.71 | GRIN2D (0.76) | EPHX2MEN1KMT2AGRIN2DGRIN3B | |
| Hydrochloric Acid SCHEMBL6336972 | 0.70 | SIGMAR1 (0.56) | EPHX2MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL8338683 | 0.70 | MEN1 (0.67) | EPHX2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL1239130 | 0.70 | EPHX2 (0.56) | EPHX2MEN1KMT2AGRIN2DGRIN3B | |
| SCHEMBL1758688 | 0.69 | GRIN2D (0.62) | EPHX2MEN1KMT2AGRIN2DGRIN3B | |
| Hydrochloric Acid SCHEMBL1677389 | 0.69 | KMT2A (0.47) | EPHX2MEN1KMT2AGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7145037-B2 | Adamantane derivatives with neuroprotective, antidepressant and anti-ischaemic activities, and process for preparing them | ROTTA RESEARCH LABORATURIUM S.P.A. (IT) | 2006-12-05 | — | — | US | disclosed |
| EP-1512679-A1 | Novel adamantane derivatives with neuroprotective, antidepressant and anti-ischaemic activities, and process for preparing them | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 2005-03-09 | — | — | EP | disclosed |
| US-20050049312-A1 | Novel adamantane derivatives with neuroprotective, antidepressant and anti-ischaemic activities,and process for preparing them | ROTTA RESEARCH LABORATORIUM S.P.A. | 2005-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050049312-A1 | Novel adamantane derivatives with neuroprotective, antidepressant and anti-ischaemic activities,and process for preparing them | BDNF, NLN, GAP43 | EPHX2 4167/4885MEN1 3114/4885KMT2A 3474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.