Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.44 |
| ▸ | CTSS | P25774 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5891850 | 0.89 | CTSS (0.54) | CTSKCTSSTSHRKMT2AMEN1 | |
| SCHEMBL5891156 | 0.89 | CALCRL (0.42) | CTSKCTSSTSHRKMT2AMEN1 | |
| SCHEMBL5144768 | 0.85 | TSHR (0.41) | CTSKCTSSTSHRKMT2AMEN1 | |
| SCHEMBL5141590 | 0.83 | TSHR (0.46) | CTSKCTSSTSHRKMT2AMEN1 | |
| SCHEMBL9089830 | 0.82 | CTSS (0.56) | CTSKCTSSTSHRALDH1A1AAK1 | |
| SCHEMBL27539175 | 0.82 | CTSS (0.56) | CTSKCTSSTSHRALDH1A1AAK1 | |
| SCHEMBL4685418 | 0.81 | KMT2A (0.57) | CTSKCTSSTSHRKMT2AMEN1 | |
| SCHEMBL5141678 | 0.81 | TSHR (0.52) | CTSKCTSSTSHRKMT2AMEN1 | |
| SCHEMBL5141638 | 0.81 | TSHR (0.45) | CTSKCTSSTSHRKMT2AMEN1 | |
| SCHEMBL5891166 | 0.81 | CTSS (0.46) | CTSKCTSSTSHRKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115609-B2 | Alanyl-piperidine heterocyclic derivatives useful against cardiovascular diseases | ELI LILLY AND COMPANY (US) | 2006-10-03 | — | — | US | disclosed |
| US-20040254374-A1 | Alanyl-piperidine heterocyclic derivatives useful against cardiovascular diseases | ELI LILLY AND COMPANY | 2004-12-16 | — | — | US | disclosed |
| EP-1456198-A1 | ALANYL-PIPERIDINE HETEROCYCLIC DERIVATIVES USEFUL AGAINST CARDIOVASCULAR DISEASES | ELI LILLY AND COMPANY (US) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003050109-A1 | ALANYL-PIPERIDINE HETEROCYCLIC DERIVATIVES USEFUL AGAINST CARDIOVASCULAR DISEASES | ELI LILLY AND COMPANY (US) | 2003-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254374-A1 | Alanyl-piperidine heterocyclic derivatives useful against cardiovascular diseases | XPNPEP1, XDH, SERPINC1 | CTSK 3274/4885CTSS 3515/4885TSHR 1686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.