⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL589481 | 1.00 | — | — | |
| SCHEMBL4421192 | 1.00 | — | — | |
| SCHEMBL714053 | 0.82 | CA2 (0.49) | — | |
| SCHEMBL85627 | 0.81 | — | — | |
| SCHEMBL7118718 | 0.81 | — | — | |
| SCHEMBL898528 | 0.81 | — | — | |
| SCHEMBL7154999 | 0.80 | CA2 (0.50) | — | |
| SCHEMBL740693 | 0.80 | — | — | |
| SCHEMBL6125258 | 0.80 | — | — | |
| SCHEMBL4135508 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100409840-C | Methods for increasing bone formation using inhibitors of glycogen synthase kinase-3 betta | HOFFMANN LA ROCHE (CH) | 2008-08-13 | — | — | CN | claimed |
| CN-117143145-A | Preparation method of dioleoyl phosphatidylethanolamine | 安徽昊帆生物有限公司 | 2023-12-01 | — | — | CN | disclosed |
| CN-113999259-A | Preparation method of (R) -glycerolphosphinyl-N-Boc ethanolamine sodium salt | 苏州昊帆生物股份有限公司 | 2022-02-01 | — | — | CN | disclosed |
| EP-2801574-B1 | ACID ADDUCT SALTS OF SUBSTITUTED PYRIDINE COMPOUND AS CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) INHIBITORS | DAIICHI SANKYO CO LTD (JP) | 2016-07-27 | — | — | EP | disclosed |
| US-9321747-B2 | Acid addition salt of substituted pyridine compound | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2016-04-26 | — | — | US | disclosed |
| US-20150299169-A1 | ACID ADDITION SALT OF SUBSTITUTED PYRIDINE COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-10-22 | — | — | US | disclosed |
| CN-102137847-B | Bicyclic heterocycles as MEK kinase inhibitors | GENENTECH INC | 2015-06-10 | — | — | CN | disclosed |
| EP-2801574-A1 | ACID ADDUCT SALT OF SUBSTITUTED PYRIDINE COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-11-12 | — | — | EP | disclosed |
| US-8114989-B2 | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2012-02-14 | — | — | US | disclosed |
| US-20100210648-A1 | PYRAZOLYLAMINOPYRIMIDINE DERIVATIVES USEFUL AS TYROSINE KINASE INHIBITORS | ASTRAZENECA R&D (SE) | 2010-08-19 | — | — | US | disclosed |
| US-7476676-B2 | Methods for increasing bone formation using inhibitors of glycogen synthase kinase-3β | ROCHE PALO ALTO LLC (US) | 2009-01-13 | — | — | US | disclosed |
| EP-1465610-B1 | USE OF A GSK-3BETA INHIBITOR IN THE MANUFACTURE OF A MEDICAMENT FOR INCREASING BONE FORMATION | HOFFMANN LA ROCHE (CH) | 2008-12-31 | — | — | EP | disclosed |
| US-20080287437-A1 | Pyrazolylaminopyrimidine Derivatives Useful as Tyrosine Kinase Inhibitors | ASTRAZENECA AB (SE) | 2008-11-20 | — | — | US | disclosed |
| CN-100409840-C | Methods for increasing bone formation using inhibitors of glycogen synthase kinase-3 betta | HOFFMANN LA ROCHE (CH) | 2008-08-13 | — | — | CN | disclosed |
| EP-1899323-A2 | PYRAZOLYLAMINOPYRIMIDINE DERIVATIVES USEFUL AS TYROSINE KINASE INHIBITORS | AstraZeneca AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006123113-A2 | PYRAZOLYLAMINOPYRIMIDINE DERIVATIVES USEFUL AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-11-23 | — | — | WO | disclosed |
| CN-1703207-A | Methods for increasing bone formation using inhibitors of glycogen synthase kinase-3 betta | HOFFMANN LA ROCHE (CH) | 2005-11-30 | — | — | CN | disclosed |
| CN-1185229-C | 3-indolyl-4-phenyl-1H-pyrrole-2, 5-dione derivatives as glycogen synthase kinase-3 beta inhibitors | HOFFMANN LA ROCHE (CH) | 2005-01-19 | — | — | CN | disclosed |
| EP-1307447-B1 | 3-INDOLYL-4-PHENYL-1H-PYRROLE-2,5-DIONE DERIVATIVES AS INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3BETA | HOFFMANN LA ROCHE (CH) | 2004-12-15 | — | — | EP | disclosed |
| US-6479490-B2 | TREATMENT OF DISEASES CHARACTERIZED BY EXCESS TH2 CYTOKINES AND/ OR AN EXCESS IGE PRODUCTION. | SYNTEX (U.S.A.) LLC | 2002-11-12 | — | — | US | disclosed |