Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 13/20 | 0.51 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 2/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | CTSC | P53634 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1687505 | 0.85 | NR1H2 (0.52) | NR1H2NR1H3KCNH2LOXL2RORC | |
| SCHEMBL5399297 | 0.83 | PTGES2 (0.53) | NR1H2NR1H3KCNH2CTSC | |
| SCHEMBL21753331 | 0.83 | NR1H2 (0.51) | NR1H2NR1H3KCNH2LOXL2RORC | |
| SCHEMBL5893176 | 0.83 | NR1H2 (0.51) | NR1H2NR1H3KCNH2LOXL2RORC | |
| SCHEMBL5893723 | 0.83 | CA2 (0.58) | — | |
| SCHEMBL7677202 | 0.82 | PTGS2 (0.49) | NR1H2NR1H3RORC | |
| SCHEMBL6243674 | 0.82 | KCNH2 (0.50) | NR1H2NR1H3KCNH2LOXL2LIMK1 | |
| SCHEMBL2140712 | 0.80 | PTGS2 (0.53) | NR1H2NR1H3KCNH2LOXL2 | |
| SCHEMBL8770103 | 0.77 | KCNH2 (0.49) | NR1H2NR1H3KCNH2LOXL2 | |
| SCHEMBL14320650 | 0.77 | CA12 (0.51) | NR1H2NR1H3KCNH2LOXL2LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141596-B2 | Inhibitors of proteins that bind phosphorylated molecules | INCYTE CORPORATION (US) | 2006-11-28 | — | — | US | disclosed |
| US-20050272778-A1 | Inhibitors of proteins that bind phosphorylated molecules | INCYTE CORPORATION | 2005-12-08 | — | — | US | disclosed |
| WO-2005035551-A2 | INHIBITORS OF PROTEINS THAT BIND PHOSPHORYLATED MOLECULES | INCYTE CORPORATION (US) | 2005-04-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272778-A1 | Inhibitors of proteins that bind phosphorylated molecules | PPP3CA, PPP5C, PPM1A | NR1H2 3488/4885NR1H3 3539/4885KCNH2 4861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.