Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 4/20 | 0.37 |
| ▸ | CHRM3 known ✓ | P20309 | 4/20 | 0.37 |
| ▸ | CHRM2 known ✓ | P08172 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6411011 | 0.82 | TDP1 (0.48) | LMNACYP2D6CYP1A2CHRM4CHRM1 | |
| Hydrochloric Acid SCHEMBL29848414 | 0.81 | THRB (0.50) | LMNACYP2D6CYP1A2CHRM4CHRM1 | |
| Hydrochloric Acid SCHEMBL5893735 | 0.80 | MEN1 (0.50) | LMNACYP2D6CHRM4CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL204259 | 0.77 | CHRM5 (0.44) | LMNACYP2D6CHRM4CHRM1CHRM3 | |
| SCHEMBL1171546 | 0.77 | CHRM5 (0.44) | LMNACYP2D6CHRM4CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL29226043 | 0.77 | CHRM5 (0.44) | LMNACYP2D6CHRM4CHRM1CHRM3 | |
| SCHEMBL10946685 | 0.76 | TDP1 (0.50) | TDP1TSHRL3MBTL1POLBAPEX1 | |
| Iodide SCHEMBL1255393 | 0.76 | CHRM5 (0.42) | LMNACYP2D6CHRM4CHRM1CHRM3 | |
| Fluoride Ion SCHEMBL1254971 | 0.76 | CHRM5 (0.42) | LMNACYP2D6CHRM4CHRM1CHRM3 | |
| Bromide SCHEMBL1254319 | 0.76 | CHRM1 (0.42) | LMNACYP2D6CHRM4CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060041053-A1 | Color filter black matrix resist composition and carbon black dispersion composition used for the composition | SHOWA DENKO K.K. (JP) | 2006-02-23 | — | — | US | disclosed |
| EP-0732346-B1 | Methacrylic copolymers and dispersants for pigments used in non-aqueous paints and varnishes comprising the copolymers | KYOEISHA CHEMICAL CO LTD (JP) | 1999-06-02 | — | — | EP | disclosed |
| US-5608025-A | CATIONIC SURFACTANTS WITH AMINOALKYL ACRYLATES | KYOEISHA CHEMICAL CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0732346-A1 | Methacrylic copolymers and dispersants for pigments used in non-aqueous paints and varnishes comprising the copolymers | Kyoeisha Chemical Co., Ltd. (JP) | 1996-09-18 | — | — | EP | disclosed |
| US-5089101-A | Protective coating comprising a cured blend of a cationic acrylic comb polymer, a cationic epoxy resin and a pigment; weatherproofing; primers; corrosion resistance | KANSAI PAINT CO., LTD. (JP) | 1992-02-18 | — | — | US | disclosed |