Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.49 |
| ▸ | ITGA2 | P17301 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CTSA | P10619 | 4/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5896878 | 0.88 | MAPT (0.47) | POLBSMN1; SMN2KMT2ALMNAALDH1A1 | |
| SCHEMBL3350832 | 0.84 | POLB (0.61) | POLBSMN1; SMN2KMT2ALMNAALDH1A1 | |
| SCHEMBL5896459 | 0.78 | ITGB1 (0.53) | POLBSMN1; SMN2KMT2ALMNAITGB3 | |
| SCHEMBL7876448 | 0.77 | POLB (0.58) | POLBSMN1; SMN2KMT2ALMNAITGB3 | |
| SCHEMBL7876188 | 0.77 | POLB (0.58) | POLBSMN1; SMN2KMT2ALMNAMAPK1 | |
| SCHEMBL536928 | 0.77 | SMN1; SMN2 (0.62) | POLBSMN1; SMN2KMT2ALMNAALDH1A1 | |
| SCHEMBL321225 | 0.76 | ITGB3 (0.54) | POLBSMN1; SMN2KMT2ALMNAALDH1A1 | |
| SCHEMBL7876199 | 0.75 | HPGD (0.52) | POLBSMN1; SMN2KMT2ALMNAALDH1A1 | |
| SCHEMBL5896951 | 0.75 | NPSR1 (0.53) | POLBSMN1; SMN2KMT2ALMNAALDH1A1 | |
| SCHEMBL7867528 | 0.75 | KMT2A (0.62) | POLBSMN1; SMN2KMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091242-B2 | Beta-amino acid derivatives as integrin receptor antagonists | BAYER AKTIENGESELLSCHAFT (DE) | 2006-08-15 | — | — | US | disclosed |
| US-20040058904-A1 | Beta-amino acid derivatives as integrin receptor antagonists | BAYER AKTIENGESELLSCHAFT (DE) | 2004-03-25 | — | — | US | disclosed |
| EP-1326828-A1 | BETA-AMINO ACID DERIVATIVES AS INTEGRIN RECEPTOR ANTAGONISTS | Bayer Aktiengesellschaft (DE) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002030875-A1 | BETA-AMINO ACID DERIVATIVES AS INTEGRIN RECEPTOR ANTAGONISTS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-04-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058904-A1 | Beta-amino acid derivatives as integrin receptor antagonists | ITGAL, ITGB1, ITGB2 | POLB 4055/4885SMN1; SMN2 3289/4885KMT2A 3922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.