Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | HPGD | P15428 | 6/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.47 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 6/20 | 0.44 |
| ▸ | GLA | P06280 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL996592 | 0.77 | NPC1 (0.53) | KDM4EALDH1A1HSD17B10GAAGLA | |
| SCHEMBL1654886 | 0.77 | EGLN2 (0.53) | KDM4EALDH1A1HPGDHSD17B10EGLN2 | |
| SCHEMBL996593 | 0.72 | RAB9A (0.50) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL7525975 | 0.69 | KMT2A (0.56) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL1356124 | 0.68 | ALDH1A1 (0.46) | ALDH1A1LMNAKMT2APOLBPKM | |
| SCHEMBL6292099 | 0.68 | NPC1 (0.49) | KDM4EALDH1A1HSD17B10GAAGLA | |
| SCHEMBL4240648 | 0.68 | PKM (0.49) | KDM4EALDH1A1HPGDHSD17B10EGLN2 | |
| SCHEMBL23702338 | 0.67 | AR (0.42) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL933304 | 0.67 | KDM4E (0.51) | KDM4EALDH1A1HSD17B10HRH3GAA | |
| SCHEMBL5897460 | 0.67 | RAB9A (0.54) | KDM4EALDH1A1GAAGLARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060700-B2 | Amide derivatives useful as inhibitors of the production of cytokines | ASTRAZENECA AB (SE) | 2006-06-13 | — | — | US | disclosed |