Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | IDO1 | P14902 | 3/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | CTSG | P08311 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | CTRC | Q99895 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL5898068 | 0.94 | CALM1 (0.47) | CALM1TSHRALDH1A1IDO1LOXL2 | |
| Fluoride Ion SCHEMBL5897336 | 0.94 | CALM1 (0.47) | CALM1TSHRALDH1A1IDO1LOXL2 | |
| Hydrochloric Acid SCHEMBL2464984 | 0.94 | CALM1 (0.47) | CALM1TSHRALDH1A1IDO1LOXL2 | |
| SCHEMBL387267 | 0.94 | CALM1 (0.47) | CALM1TSHRALDH1A1IDO1LOXL2 | |
| SCHEMBL11787258 | 0.94 | CALM1 (0.47) | CALM1TSHRALDH1A1IDO1LOXL2 | |
| SCHEMBL10623542 | 0.86 | CALM1 (0.41) | CALM1TSHRALDH1A1IDO1LOXL2 | |
| Fumaric Acid SCHEMBL385037 | 0.75 | CES2 (0.45) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1029970 | 0.69 | CALM1 (0.41) | CALM1TSHRALDH1A1IDO1LOXL2 | |
| Diphenylmethane SCHEMBL1303 | 0.65 | CALM1 (1.00) | CALM1TSHRALDH1A1IDO1LOXL2 | |
| SCHEMBL9741303 | 0.65 | ALDH1A1 (0.69) | CALM1ALDH1A1LOXL2MAOBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7008899-B2 | Lanthanide-based catalyst composition for producing cis-1,4-polydienes | BRIDGESTONE CORPORATION (JP) | 2006-03-07 | — | — | US | claimed |
| US-20050038215-A1 | Lanthanide-based catalyst composition for producing cis-1,4-polydienes | BRIDGESTONE CORPORATION (JP) | 2005-02-17 | — | — | US | claimed |
| US-5929238-A | REACTING DIBENZYLTIN DIHALIDE, DIISOCYANATE, DITHIOCYANATE OR DIISOTHIOCYANATE WITH APPROPRIATE LIGAND IN NON-POLAR HALOGEN-FREE ORGANIC SOLVENT, SEPARATING COMPLEX FROM MIXTURE | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 1999-07-27 | — | — | US | claimed |
| US-7008899-B2 | Lanthanide-based catalyst composition for producing cis-1,4-polydienes | BRIDGESTONE CORPORATION (JP) | 2006-03-07 | — | — | US | disclosed |
| US-20050038215-A1 | Lanthanide-based catalyst composition for producing cis-1,4-polydienes | BRIDGESTONE CORPORATION (JP) | 2005-02-17 | — | — | US | disclosed |
| US-4148814-A | Process for preparing monohydrocarbyltin trihalides | PENNWALT CORPORATION (US) | 1979-04-10 | — | — | US | disclosed |