Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LEF1 | Q9UJU2 | 1/20 | 0.50 |
| ▸ | PLD2 | O14939 | 1/20 | 0.47 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PRNP | P04156 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5896829 | 0.95 | LEF1 (0.47) | LEF1PLD2PLD1EGFRPIK3CA | |
| SCHEMBL5896935 | 0.94 | LEF1 (0.58) | LEF1PLD2PLD1EGFRPIK3CA | |
| SCHEMBL5896865 | 0.84 | LEF1 (0.54) | LEF1NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL20266986 | 0.84 | HRH3 (0.52) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL5896957 | 0.84 | HRH3 (0.46) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL5896620 | 0.84 | KDM4E (0.50) | PLD2PLD1EGFRPIK3CAKDM4E | |
| SCHEMBL20289864 | 0.83 | KDM4E (0.49) | LEF1NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL5896655 | 0.83 | KDM4E (0.51) | PLD2PLD1EGFRPIK3CAKDM4E | |
| SCHEMBL5896814 | 0.82 | PYGL (0.48) | PLD2PLD1EGFRPIK3CANPC1 | |
| SCHEMBL5896864 | 0.81 | LEF1 (0.51) | LEF1PLD2PLD1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141680-B2 | Aromatic compounds possessing antifungal or antibacterial activity | GENELABS TECHNOLOGIES, INC. | 2006-11-28 | — | — | US | disclosed |