Iodohippurate

Iodohippurate

SCHEMBL589803

O=C(O)CNC(=O)c1ccccc1I

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.58
MEN1 O00255 1/20 0.58
TDP1 Q9NUW8 1/20 0.58
KEAP1 Q14145 1/20 0.54
EGLN1 Q9GZT9 3/20 0.48
KDM4C Q9H3R0 1/20 0.45
KDM4E B2RXH2 1/20 0.44
MAPT P10636 1/20 0.44
HIF1A Q16665 1/20 0.44
SLC22A6 Q4U2R8 1/20 0.44
SLC22A8 Q8TCC7 1/20 0.44
RAB9A P51151 1/20 0.44
SIGMAR1 Q99720 1/20 0.43
ABAT P80404 1/20 0.43
APEX1 P27695 1/20 0.43
PTPRC P08575 2/20 0.43
CTSL P07711 1/20 0.43
PTPN13 Q12923 1/20 0.43
GAA P10253 1/20 0.43
ABL1 P00519 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Iodohippurate SCHEMBL29959499 1.00 KMT2A (0.58) KMT2AMEN1TDP1KEAP1EGLN1
Iodohippurate SCHEMBL2142713 0.98 KMT2A (0.56) KMT2AMEN1TDP1KEAP1EGLN1
Iodohippurate SCHEMBL5915006 0.98 KMT2A (0.56) KMT2AMEN1TDP1KEAP1EGLN1
Iodohippurate SCHEMBL9860635 0.98 KMT2A (0.56) KMT2AMEN1TDP1KEAP1EGLN1
SCHEMBL31448014 0.86 KEAP1 (0.62) KMT2AKEAP1EGLN1KDM4CKDM4E
SCHEMBL5532912 0.86 KEAP1 (0.51) KMT2AMEN1TDP1KEAP1EGLN1
SCHEMBL11325406 0.84 KMT2A (0.51) KMT2AMEN1TDP1KEAP1SIGMAR1
SCHEMBL8814831 0.84 KMT2A (0.51) KMT2AMEN1TDP1KEAP1SIGMAR1
Iodohippurate SCHEMBL5915003 0.82 KMT2A (0.50) KMT2AMEN1TDP1KEAP1SIGMAR1
Iodohippurate SCHEMBL1652159 0.82 KMT2A (0.50) KMT2AMEN1TDP1KEAP1SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 418 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240350644-A1 STEREOCOMPLEXES FOR THE DELIVERY OF ANTI-CANCER AGENTS TIEN DER YANG (US) 2024-10-24 US claimed
CN-118184679-A Photothermal agent and preparation method thereof, photothermal nanoparticle and preparation method thereof, insulating material and self-repairing method of insulating material 中国石油天然气股份有限公司 2024-06-14 CN claimed
CN-115671286-B Stereocomplex for delivery of anticancer agents 田德扬 2023-12-08 CN claimed
EP-4137527-A1 STEREOCOMPLEXES FOR THE DELIVERY OF ANTI-CANCER AGENTS TIEN, Der-Yang (US) 2023-02-22 EP claimed
CN-115671286-A Stereocomplex for delivery of anticancer agents 田德扬 2023-02-03 CN claimed
CN-113260653-B Stereocomplex for delivery of anticancer agents 田德扬 2022-11-04 CN claimed
EP-3891207-B1 STEREOCOMPLEXES FOR THE DELIVERY OF ANTI-CANCER AGENTS TIEN DER YANG (US) 2022-11-02 EP claimed
US-20220072139-A1 STEREOCOMPLEXES FOR THE DELIVERY OF ANTI-CANCER AGENTS TIEN DER YANG (US) 2022-03-10 US claimed
EP-3891207-A1 STEREOCOMPLEXES FOR THE DELIVERY OF ANTI-CANCER AGENTS TIEN, Der-Yang (US) 2021-10-13 EP claimed
WO-2020117742-A1 STEREOCOMPLEXES FOR THE DELIVERY OF ANTI-CANCER AGENTS TIEN DER YANG (US) 2020-06-11 WO claimed
CN-100482284-C Tracer or labelled isotope microbubble reagent with target substance and usage thereof WEI WU (CN) 2009-04-29 CN claimed
US-20070060906-A1 Method, reagent, and device for embolizing blood vessels in tumors with ultrasonic radiation micro-bubble reagent WU WEI 2007-03-15 US claimed
US-20060019205-A1 Thermographic materials processable at lower temperatures EASTMAN KODAK COMPANY 2006-01-26 US claimed
CN-1669586-A Tracer or labelled isotope microbubble reagent with target substance and usage thereof WU WEI (CN) 2005-09-21 CN claimed
US-5225182-A For specific organ delivery SHARMA YASH P (US) 1993-07-06 US claimed
US-5021220-A Haluaromatic compound, water-soluble acid, copper salt acid-stable reducing agent MALLINCKRODT, INC. (US) 1991-06-04 US claimed
US-4883650-A Radioidohippuric acid ester, a conjugate thereof, and methods of making the same ALBERT EINSTEIN COLLEGE OF MEDICINE - OF YESHIVA UNIVERSITY (US) 1989-11-28 US claimed
EP-0165630-B1 METHOD OF PREPARING A CHLORINATED, BROMINATED, RADIOBROMINATED, IODINATED AND/OR RADIOIODINATED, AROMATIC OR HETEROAROMATIC COMPOUND, AS WELL AS A KIT FOR PREPARING A DIAGNOSTIC COMPOSITION ON THE BASIS OF THIS COMPOUND MALLINCKRODT, INC.(a Missouri corporation) (US) 1989-10-18 EP claimed
EP-0165630-A2 Method of preparing a chlorinated, brominated, radiobrominated, iodinated and/or radioiodinated, aromatic or heteroaromatic compound, as well as a kit for preparing a diagnostic composition on the basis of this compound MALLINCKRODT, INC.(a Missouri corporation) (US) 1985-12-27 EP claimed
US-4192859-A MEDICAL DIAGNOSIS USING X-RAYS E. R. SQUIBB & SONS, INC. (US) 1980-03-11 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220072139-A1 STEREOCOMPLEXES FOR THE DELIVERY OF ANTI-CANCER AGENTS TOP2A, TSG101, TOP1 KMT2A 4641/4885MEN1 1549/4885TDP1 1435/4885
US-20240350644-A1 STEREOCOMPLEXES FOR THE DELIVERY OF ANTI-CANCER AGENTS TOP2A, TSG101, TOP1 KMT2A 4641/4885MEN1 1549/4885TDP1 1435/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.