SCHEMBL589853

SCHEMBL589853

CN(C(=O)c1cc(Cl)ccc1NC(=O)c1cc(Br)nn1-c1ncccc1Cl)C1CC1

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 3/20 0.41
TRPV1 Q8NER1 2/20 0.39
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
MALT1 Q9UDY8 3/20 0.37
RBP4 P02753 2/20 0.36
CNR1 P21554 1/20 0.35
HPGD P15428 1/20 0.35
TSHR P16473 1/20 0.35
PPARG P37231 1/20 0.35
PDE4A P27815 1/20 0.34
PDE4B Q07343 1/20 0.34
PDE4C Q08493 1/20 0.34
PDE4D Q08499 1/20 0.34
SERPINE1 P05121 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12528821 0.90 DHODH (0.44) DHODHTRPV1RBP4PPARGSERPINE1
SCHEMBL950194 0.88 DHODH (0.43) DHODHTRPV1RBP4PPARGSERPINE1
SCHEMBL929326 0.88 DHODH (0.38) DHODHMALT1HPGDTSHR
SCHEMBL951378 0.87 DHODH (0.43) DHODHTRPV1RBP4HPGDTSHR
SCHEMBL12528032 0.86 DHODH (0.42) DHODHTRPV1RBP4HPGDTSHR
SCHEMBL12911773 0.86 DHODH (0.42) DHODHTRPV1MALT1RBP4PPARG
SCHEMBL13072493 0.85 DHODH (0.43) DHODHTRPV1RBP4PPARGSERPINE1
SCHEMBL13072415 0.84 DHODH (0.43) DHODHTRPV1RBP4PPARGSERPINE1
SCHEMBL589798 0.83 DHODH (0.41) DHODHTRPV1NPC1RAB9AMALT1
SCHEMBL31438692 0.83 DHODH (0.41) DHODHTRPV1NPC1RAB9AMALT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2093223-B1 PROCESS AND INTERMEDIATES FOR PRODUCTION OF AN ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA (JP) 2013-08-21 EP disclosed
US-8115006-B2 Process for producing anthranilamide compound ISHIHARA SANGYO KAISHA, LTD. (JP) 2012-02-14 US disclosed
US-20100063293-A1 PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA ,LTD. (JP) 2010-03-11 US disclosed
EP-2093223-A1 PROCESS FOR PRODUCTION OF ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA, LTD. (JP) 2009-08-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100063293-A1 PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND NAAA, AAAS, AADAC DHODH 927/4885TRPV1 3266/4885NPC1 4477/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.