SCHEMBL589798

SCHEMBL589798

CC(NC(=O)c1cc(Cl)ccc1NC(=O)c1cc(Br)nn1-c1ncccc1Cl)C1CC1

nearest known ligand 0.55

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 3/20 0.41
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
TRPV1 Q8NER1 2/20 0.38
F10 P00742 1/20 0.38
IDO1 P14902 4/20 0.38
NAMPT P43490 2/20 0.37
MALT1 Q9UDY8 1/20 0.36
RBP4 P02753 1/20 0.36
CCR8 P51685 1/20 0.35
IRAK1 P51617 1/20 0.35
IRAK4 Q9NWZ3 1/20 0.35
RIPK1 Q13546 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31438692 1.00 DHODH (0.41) DHODHNPC1RAB9ATRPV1F10
SCHEMBL29416624 0.89 IDO1 (0.38) DHODHNPC1RAB9AIDO1NAMPT
SCHEMBL196132 0.89 IDO1 (0.38) DHODHNPC1RAB9AIDO1NAMPT
SCHEMBL590485 0.88 TRPV1 (0.42) NPC1RAB9ATRPV1F10IDO1
SCHEMBL29355401 0.88 IDO1 (0.38) DHODHNPC1RAB9AIDO1NAMPT
SCHEMBL27174182 0.88 IDO1 (0.38) DHODHNPC1RAB9AIDO1NAMPT
SCHEMBL29416636 0.88 IDO1 (0.38) DHODHNPC1RAB9AIDO1NAMPT
SCHEMBL230723 0.88 IDO1 (0.38) DHODHNPC1RAB9AIDO1NAMPT
SCHEMBL29416550 0.87 DHODH (0.40) DHODHNPC1RAB9AIDO1NAMPT
SCHEMBL195314 0.87 DHODH (0.40) DHODHNPC1RAB9AIDO1NAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2093223-B1 PROCESS AND INTERMEDIATES FOR PRODUCTION OF AN ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA (JP) 2013-08-21 EP disclosed
US-8481744-B2 Process for producing anthranilamide compound ISHIHARA SANGYO KAISHA, LTD. (JP) 2013-07-09 US disclosed
EP-2264021-B1 PROCESS FOR PRODUCING AN ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA (JP) 2013-06-26 EP disclosed
US-8115006-B2 Process for producing anthranilamide compound ISHIHARA SANGYO KAISHA, LTD. (JP) 2012-02-14 US disclosed
US-20110034696-A1 PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA, LTD. (JP) 2011-02-10 US disclosed
EP-2264021-A1 PROCESS FOR PRODUCING AN ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA, LTD. (JP) 2010-12-22 EP disclosed
US-20100063293-A1 PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA ,LTD. (JP) 2010-03-11 US disclosed
EP-2093223-A1 PROCESS FOR PRODUCTION OF ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA, LTD. (JP) 2009-08-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100063293-A1 PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND NAAA, AAAS, AADAC DHODH 927/4885NPC1 4477/4885RAB9A 146/4885
US-20110034696-A1 PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND SQOR, NOX5, NOX3 DHODH 149/4885NPC1 4819/4885RAB9A 1361/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.