Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 20/20 | 0.62 |
| ▸ | ALK | Q9UM73 | 20/20 | 0.62 |
| ▸ | IGF1R | P08069 | 14/20 | 0.62 |
| ▸ | AURKA | O14965 | 2/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.60 |
| ▸ | PRKCG | P05129 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | FYN | P06241 | 1/20 | 0.60 |
| ▸ | CSF1R | P07333 | 1/20 | 0.60 |
| ▸ | LYN | P07948 | 1/20 | 0.60 |
| ▸ | RET | P07949 | 1/20 | 0.60 |
| ▸ | MET | P08581 | 1/20 | 0.60 |
| ▸ | ROS1 | P08922 | 1/20 | 0.60 |
| ▸ | KIT | P10721 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL591315 | 0.94 | ALK (0.61) | INSRALKIGF1RAURKAAURKB | |
| SCHEMBL590555 | 0.89 | INSR (0.59) | INSRALKIGF1RAURKAAURKB | |
| SCHEMBL592569 | 0.89 | ALK (0.57) | INSRALKIGF1RAURKAAURKB | |
| SCHEMBL590650 | 0.88 | INSR (0.60) | INSRALKIGF1RAURKAAURKB | |
| SCHEMBL589806 | 0.88 | INSR (0.62) | INSRALKIGF1RAURKAAURKB | |
| SCHEMBL591035 | 0.88 | INSR (0.72) | INSRALKIGF1RAURKAAURKB | |
| SCHEMBL589690 | 0.87 | INSR (0.78) | INSRALKIGF1RAURKAAURKB | |
| SCHEMBL591234 | 0.87 | INSR (0.58) | INSRALKIGF1RAURKAAURKB | |
| SCHEMBL590678 | 0.87 | INSR (0.62) | INSRALKIGF1RAURKAAURKB | |
| SCHEMBL589626 | 0.87 | INSR (0.59) | INSRALKIGF1RAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120932-B1 | INDAZOLE DERIVATIVES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | NERVIANO MEDICAL SCIENCES SRL (IT) | 2014-07-09 | — | — | EP | claimed |
| US-8114865-B2 | Indazole derivatives as kinase inhibitors for the treatment of cancer | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-14 | — | — | US | claimed |
| US-20100197665-A1 | INDAZOLE DERIVATIVES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-08-05 | — | — | US | claimed |
| EP-3834827-A1 | N-[5-(3,5-DIFLUOROBENZYL)-1H-INDAZOL-3-YL]-4-(4-METHYL-PIPERAZIN-1-YL)-2-(TETRAHYDRO-2H-PYRAN-4-YLAMINO) BENZAMIDE FOR TREATING PATIENTS WITH ROS1,NTRK1, NTRK2 AND NTRK3 MUTANT CANCER CELLS | Ignyta, Inc. (US) | 2021-06-16 | — | — | EP | disclosed |
| EP-3107541-B1 | COMPOUNDS FOR TREATING PATIENTS WITH ROS1 MUTANT CANCER CELLS | IGNYTA INC (US) | 2020-12-23 | — | — | EP | disclosed |
| US-10682348-B2 | Molecules for administration to ROS1 mutant cancer cells | IGNYTA, INC. (US) | 2020-06-16 | — | — | US | disclosed |
| US-10561651-B2 | Methods for treating neuroblastoma | IGNYTA, INC. (US) | 2020-02-18 | — | — | US | disclosed |
| US-20190282564-A1 | MOLECULES FOR ADMINISTRATION TO ROS1 MUTANT CANCER CELLS | IGNYTA, INC. | 2019-09-19 | — | — | US | disclosed |
| US-10231965-B2 | Molecules for administration to ROS1 mutant cancer cells | IGNYTA, INC. (US) | 2019-03-19 | — | — | US | disclosed |
| US-20180333412-A1 | METHODS FOR TREATING NEUROBLASTOMA | IGNYTA, INC. (US) | 2018-11-22 | — | — | US | disclosed |
| US-20170007599-A1 | METHODS FOR TREATING NEUROBLASTOMA | IGNYTA, INC. | 2017-01-12 | — | — | US | disclosed |
| US-8114865-B2 | Indazole derivatives as kinase inhibitors for the treatment of cancer | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-14 | — | — | US | disclosed |
| US-20100197665-A1 | INDAZOLE DERIVATIVES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-08-05 | — | — | US | disclosed |
| US-20100197665-A1 | INDAZOLE DERIVATIVES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-08-05 | — | — | US | disclosed |
| US-20100197665-A1 | INDAZOLE DERIVATIVES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-08-05 | — | — | US | disclosed |
| EP-2120932-A1 | INDAZOLE DERIVATIVES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | Nerviano Medical Sciences S.r.l. (IT) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008074749-A9 | INDAZOLE DERIVATIVES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | NERVIANO MEDICAL SCIENCES SRL (IT) | 2009-05-07 | — | — | WO | disclosed |
| WO-2008074749-A9 | INDAZOLE DERIVATIVES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | NERVIANO MEDICAL SCIENCES SRL (IT) | 2009-05-07 | — | — | WO | disclosed |
| WO-2008074749-A1 | INDAZOLE DERIVATIVES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008074749-A1 | INDAZOLE DERIVATIVES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170007599-A1 | METHODS FOR TREATING NEUROBLASTOMA | NEK2, CSNK1G3, AHNAK | INSR 668/4885ALK 556/4885IGF1R 215/4885 |
| US-20100197665-A1 | INDAZOLE DERIVATIVES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | MAP3K5, MAP3K19, MAP3K3 | INSR 400/4885ALK 420/4885IGF1R 117/4885 |
| US-10561651-B2 | Methods for treating neuroblastoma | UBTF, CABLES1, WEE2 | INSR 1551/4885ALK 1037/4885IGF1R 299/4885 |
| US-10682348-B2 | Molecules for administration to ROS1 mutant cancer cells | ROS1, KRAS, NOX1 | INSR 303/4885ALK 337/4885IGF1R 72/4885 |
| US-10231965-B2 | Molecules for administration to ROS1 mutant cancer cells | ROS1, KRAS, NOX1 | INSR 303/4885ALK 337/4885IGF1R 72/4885 |
| US-20190282564-A1 | MOLECULES FOR ADMINISTRATION TO ROS1 MUTANT CANCER CELLS | ROS1, KRAS, NOX1 | INSR 303/4885ALK 337/4885IGF1R 72/4885 |
| US-20180333412-A1 | METHODS FOR TREATING NEUROBLASTOMA | UBTF, CABLES1, WEE2 | INSR 1551/4885ALK 1037/4885IGF1R 299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.