Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.59 |
| ▸ | KDM1A | O60341 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.56 |
| ▸ | HPGDS | O60760 | 1/20 | 0.55 |
| ▸ | AKT1 | P31749 | 1/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.51 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.51 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.51 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4804463 | 0.87 | KDM1A (0.58) | CHEK2KDM1AHDAC1MAP4K4CA1 | |
| SCHEMBL5904122 | 0.86 | CHEK2 (0.78) | CHEK2MAP4K4HPGDSMAPKAPK2MKNK1 | |
| SCHEMBL5904261 | 0.86 | CHEK2 (0.59) | CHEK2MAP4K4HPGDSPARP10PARP1 | |
| SCHEMBL4674159 | 0.80 | AKT1 (0.70) | CHEK2MAP4K4HPGDSAKT1PARP1 | |
| SCHEMBL28414233 | 0.80 | MALT1 (0.57) | KDM1AHDAC1CA1CA2CYP11B1 | |
| SCHEMBL25060774 | 0.79 | MALT1 (0.55) | CHEK2KDM1AHDAC1MAP4K4PARP10 | |
| SCHEMBL22332440 | 0.78 | MALT1 (0.55) | CHEK2KDM1AHDAC1MAP4K4PARP10 | |
| SCHEMBL20987083 | 0.76 | KDM1A (0.51) | CHEK2KDM1AHDAC1MAP4K4CA1 | |
| SCHEMBL20987099 | 0.76 | HDAC1 (0.53) | CHEK2KDM1AHDAC1MAP4K4CA1 | |
| SCHEMBL28419710 | 0.76 | MALT1 (0.53) | KDM1AHDAC1MALT1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060128757-A1 | Pyridine derivatives useful as cyclooxygenase inhibitor | ASTELLAS PHARMA INC. (JP) | 2006-06-15 | — | — | US | disclosed |
| EP-1355885-A1 | PYRIDINE DERIVATIVES USEFUL AS CYCLOOXYGENASE INHIBITOR | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-10-29 | — | — | EP | disclosed |
| US-20030119877-A1 | Pyridine derivatives useful as cyclooxygenase inhibitor | ASTELLAS PHARMA INC. (JP) | 2003-06-26 | — | — | US | disclosed |
| WO-2002055502-A1 | PYRIDINE DERIVATIVES USEFUL AS CYCLOOXYGENASE INHIBITOR | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-07-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119877-A1 | Pyridine derivatives useful as cyclooxygenase inhibitor | PTGS1, PTGIS, PTGER1 | CHEK2 3171/4885KDM1A 408/4885HDAC1 975/4885 |
| US-20060128757-A1 | Pyridine derivatives useful as cyclooxygenase inhibitor | PTGS1, PTGIS, PTGS2 | CHEK2 2590/4885KDM1A 183/4885HDAC1 783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.