Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 5/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.46 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5772476 | 0.84 | SLC6A4 (0.46) | TLR8CNR1SLC6A4C5AR1GSTP1 | |
| SCHEMBL6069616 | 0.81 | PTGS2 (0.55) | — | |
| SCHEMBL16879470 | 0.76 | GSTP1 (0.55) | NPSR1MAPTGSTP1MAOB | |
| SCHEMBL16879689 | 0.76 | GSTP1 (0.55) | NPSR1LMNAMAPTMAPK1CNR1 | |
| SCHEMBL31381827 | 0.76 | CNR2 (0.46) | ALDH1A1LMNAMAPTMAPK1CNR1 | |
| SCHEMBL6069619 | 0.75 | PTGER1 (0.48) | SLC6A4 | |
| SCHEMBL5109364 | 0.75 | SLC6A4 (0.50) | NPSR1CNR1SLC6A4MAOB | |
| SCHEMBL16879636 | 0.73 | MAOB (0.51) | ALDH1A1LMNAHTTMAPTMAPK1 | |
| SCHEMBL28871638 | 0.73 | SQOR (0.62) | NPSR1ALDH1A1LMNAHTTMAPT | |
| SCHEMBL5904170 | 0.73 | PTGS2 (0.52) | NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060128757-A1 | Pyridine derivatives useful as cyclooxygenase inhibitor | ASTELLAS PHARMA INC. (JP) | 2006-06-15 | — | — | US | disclosed |
| EP-1355885-A1 | PYRIDINE DERIVATIVES USEFUL AS CYCLOOXYGENASE INHIBITOR | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-10-29 | — | — | EP | disclosed |
| US-20030119877-A1 | Pyridine derivatives useful as cyclooxygenase inhibitor | ASTELLAS PHARMA INC. (JP) | 2003-06-26 | — | — | US | disclosed |
| WO-2002055502-A1 | PYRIDINE DERIVATIVES USEFUL AS CYCLOOXYGENASE INHIBITOR | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-07-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119877-A1 | Pyridine derivatives useful as cyclooxygenase inhibitor | PTGS1, PTGIS, PTGER1 | NPSR1 1498/4885ALDH1A1 177/4885LMNA 4281/4885 |
| US-20060128757-A1 | Pyridine derivatives useful as cyclooxygenase inhibitor | PTGS1, PTGIS, PTGS2 | NPSR1 479/4885ALDH1A1 314/4885LMNA 4302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.