Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 9/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5907477 | 0.83 | BRD9 (0.45) | ALDH1A1HPGDSMN1; SMN2TGFBR1L3MBTL1 | |
| SCHEMBL5956366 | 0.83 | FKBP1A (0.47) | FKBP1AALDH1A1HPGDUSP2SMN1; SMN2 | |
| SCHEMBL5907496 | 0.81 | TGFBR1 (0.56) | HPGDTGFBR1 | |
| SCHEMBL5907478 | 0.79 | TGFBR1 (0.56) | TGFBR1ACHE | |
| SCHEMBL28552520 | 0.79 | TGFBR1 (0.42) | TGFBR1 | |
| SCHEMBL25085126 | 0.79 | TMEM97 (0.43) | FKBP1AALDH1A1HPGDUSP2SMN1; SMN2 | |
| SCHEMBL30156238 | 0.79 | TMEM97 (0.43) | FKBP1AALDH1A1HPGDUSP2SMN1; SMN2 | |
| SCHEMBL23873733 | 0.79 | CYP1A2 (0.44) | ALDH1A1HPGDSMN1; SMN2TGFBR1L3MBTL1 | |
| SCHEMBL5907473 | 0.78 | TGFBR1 (0.47) | TGFBR1 | |
| SCHEMBL5907494 | 0.77 | FKBP1A (0.52) | FKBP1AALDH1A1HPGDUSP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060058329-A1 | Pyrazole inhibitors of the transforming growth factor | SMITHKLINE BEECHAM CORPORATION | 2006-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058329-A1 | Pyrazole inhibitors of the transforming growth factor | SMAD3, SMAD2, TGFBR1 | FKBP1A 695/4885ALDH1A1 3456/4885HPGD 3693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.