Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 5/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5908741 | 0.91 | KDM4E (0.39) | GAAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6499194 | 0.88 | PIK3CA (0.34) | PRKD3PIM1GSK3AGSK3BIRAK1 | |
| SCHEMBL6498293 | 0.80 | ALDH1A1 (0.39) | GAAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL5908454 | 0.72 | KDM4E (0.35) | GAALMNAKDM4EALDH1A1HPGD | |
| SCHEMBL5908450 | 0.72 | KDM4E (0.35) | GAALMNAKDM4EALDH1A1HPGD | |
| SCHEMBL5908463 | 0.72 | KDM4E (0.35) | GAALMNAKDM4EALDH1A1HPGD | |
| SCHEMBL5777367 | 0.70 | KDM4E (0.48) | GAALMNAMEN1KMT2AKDM4E | |
| SCHEMBL5908263 | 0.69 | ALDH1A1 (0.51) | GAALMNAMEN1KMT2AKDM4E | |
| SCHEMBL5814129 | 0.66 | ADORA2A (0.35) | LMNAMAPK8MEN1KMT2AKDM4E | |
| SCHEMBL30482929 | 0.66 | PIM1 (0.41) | PRKD3PIM1GSK3AGSK3BIRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7056917-B2 | Drug efflux pump inhibitor | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-06-06 | — | — | US | disclosed |
| US-20060106034-A1 | Drug efflux pump inhibitor | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-05-18 | — | — | US | disclosed |
| US-20030092720-A1 | Drug efflux pump inhibitor | DAIICHI PHARMACEUTICAL CO., LTD (JP) | 2003-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030092720-A1 | Drug efflux pump inhibitor | ABCB11, ABCB1, ABCC1 | PRKD3 2985/4885PIM1 1360/4885GSK3A 2470/4885 |
| US-20060106034-A1 | Drug efflux pump inhibitor | ABCB11, ABCB1, ABCC5 | PRKD3 2584/4885PIM1 1818/4885GSK3A 4148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.