Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | SPR | P35270 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | UBE2M | P61081 | 1/20 | 0.41 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5908976 | 0.86 | AKR1C3 (0.47) | ALDH1A1HPGDKDM4EPOLBTSHR | |
| SCHEMBL5909264 | 0.84 | L3MBTL1 (0.48) | L3MBTL1HRH4ALDH1A1HPGDKDM4E | |
| SCHEMBL5909304 | 0.83 | ALDH1A1 (0.59) | L3MBTL1ALDH1A1KDM4ETSHRKMT2A | |
| SCHEMBL5909259 | 0.78 | ALDH1A1 (0.61) | ALDH1A1KDM4EUSP2TSHRKMT2A | |
| SCHEMBL5908888 | 0.76 | ALDH1A1 (0.57) | ALDH1A1HPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL5909090 | 0.75 | ALDH1A1 (0.59) | ALDH1A1KDM4EPOLBTSHRTDP1 | |
| SCHEMBL11960839 | 0.74 | SMN1; SMN2 (0.52) | ALDH1A1HPGDKDM4EPOLBUSP2 | |
| SCHEMBL13693067 | 0.74 | HSD11B1 (0.46) | HSD11B1HRH4ALDH1A1HPGDKDM4E | |
| SCHEMBL14899243 | 0.73 | HTT (0.71) | HSD11B1ALDH1A1HPGDUSP2TSHR | |
| SCHEMBL21414457 | 0.72 | HRH3 (0.55) | ALDH1A1HPGDKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060030557-A1 | Substituted pyridines having antiangiogenic activity | HAVIV FORTUNA | 2006-02-09 | — | — | US | disclosed |
| US-20040014744-A1 | Substituted pyridines having antiangiogenic activity | ABBOTT LABORATORIES | 2004-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014744-A1 | Substituted pyridines having antiangiogenic activity | FLT1, FLT4, KDR | L3MBTL1 4650/4885HSD11B1 1954/4885HRH4 3332/4885 |
| US-20060030557-A1 | Substituted pyridines having antiangiogenic activity | FLT4, KDR, FLT1 | L3MBTL1 4745/4885HSD11B1 3211/4885HRH4 2788/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.