Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23178156 | 0.84 | GAA (0.67) | HDAC1GAAEPHX2ALDH1A1HDAC2 | |
| SCHEMBL5913902 | 0.82 | GAA (0.56) | HDAC1GAAALDH1A1HDAC2KDM4E | |
| SCHEMBL5767632 | 0.82 | NOTUM (0.57) | HDAC1GAAEPHX2ALDH1A1HDAC2 | |
| SCHEMBL3324621 | 0.81 | LTA4H (0.67) | ALDH1A1RECQLMAPTHTTMEN1 | |
| SCHEMBL4529276 | 0.81 | CA1 (0.63) | HDAC1GAAEPHX2CA1CA2 | |
| SCHEMBL14107963 | 0.79 | MAPT (0.58) | GAAEPHX2ALDH1A1KDM4ERECQL | |
| SCHEMBL23660445 | 0.79 | EPHX2 (0.53) | HDAC1GAAEPHX2ALDH1A1HDAC2 | |
| SCHEMBL4522193 | 0.78 | GAA (0.55) | HDAC1GAAALDH1A1HDAC2KDM4E | |
| SCHEMBL8195648 | 0.78 | CDK1 (0.55) | GAAEPHX2ALDH1A1KDM4EL3MBTL1 | |
| Hydrochloric Acid SCHEMBL5967195 | 0.78 | KDM4E (0.65) | HDAC1GAAALDH1A1KDM4ERECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114671880-B | Synthesis and application of indole-2, 3-dinitrile antitumor compounds containing fatty amino | 大连理工大学 | 2023-06-06 | — | — | CN | claimed |
| CN-114671880-A | Synthesis and application of indole-2, 3-dinitrile antitumor compound containing aliphatic amino | 大连理工大学 | 2022-06-28 | — | — | CN | claimed |
| CN-114671880-B | Synthesis and application of indole-2, 3-dinitrile antitumor compounds containing fatty amino | 大连理工大学 | 2023-06-06 | — | — | CN | disclosed |
| CN-114671880-A | Synthesis and application of indole-2, 3-dinitrile antitumor compound containing aliphatic amino | 大连理工大学 | 2022-06-28 | — | — | CN | disclosed |
| CN-114671880-A | Synthesis and application of indole-2, 3-dinitrile antitumor compound containing aliphatic amino | 大连理工大学 | 2022-06-28 | — | — | CN | disclosed |
| WO-2020211563-A1 | INDAZOLE COMPOUNDS, PREPARATION METHOD THEREFOR AND USE THEREOF | 浙江大学 | 2020-10-22 | — | — | WO | disclosed |
| US-20180134662-A1 | Aminopyridine Based Buffers with Wide Buffering Ranges Antibiotics and Myelin Disease Therapy | TPAT IP LLC | 2018-05-17 | — | — | US | disclosed |
| US-9867813-B2 | Aminopyridine based buffers with wide buffering ranges, antibiotics and myelin disease therapy | TPAT IP LLC | 2018-01-16 | — | — | US | disclosed |
| US-20170135998-A1 | Aminopyridine Based Buffers with Wide Buffering Ranges, Antibiotics and Myelin Disease Therapy | TPAT IP LLC | 2017-05-18 | — | — | US | disclosed |
| US-20060223826-A1 | Indole derivatives as somatostatin agonists or antagonists | TAKEDA PHARMACEUTICAL COMPANY LIMITED INTELLECTUAL PROPERTY DEPARTMENT (JP) | 2006-10-05 | — | — | US | disclosed |
| EP-1562898-A1 | INDOLE DERIVATIVES AS SOMATOSTATIN AGONISTS OR ANTAGONISTS | Takeda Pharmaceutical Company Limited (JP) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004046107-A1 | INDOLE DERIVATIVES AS SOMATOSTATIN AGONISTS OR ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223826-A1 | Indole derivatives as somatostatin agonists or antagonists | SSTR1, SSTR3, NPY1R | HDAC1 202/4885GAA 1823/4885EPHX2 3960/4885 |
| US-20180134662-A1 | Aminopyridine Based Buffers with Wide Buffering Ranges Antibiotics and Myelin Disease Therapy | AQP4, PMP22, MAG | HDAC1 2045/4885GAA 779/4885EPHX2 4145/4885 |
| US-20170135998-A1 | Aminopyridine Based Buffers with Wide Buffering Ranges, Antibiotics and Myelin Disease Therapy | AQP4, PMP22, MAG | HDAC1 2464/4885GAA 962/4885EPHX2 3995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.