Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 13/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5888 | 0.80 | EPHX2 (0.49) | FFAR4DRD3EPHX2 | |
| SCHEMBL1588919 | 0.77 | LIPE (0.58) | OPRL1 | |
| SCHEMBL9942 | 0.77 | LIPE (0.58) | OPRL1 | |
| SCHEMBL9943 | 0.77 | LIPE (0.58) | OPRL1 | |
| SCHEMBL26552871 | 0.76 | ALDH1A1 (0.47) | EPHX2 | |
| SCHEMBL622213 | 0.74 | FFAR4 (0.46) | FFAR4DRD3EPHX2 | |
| SCHEMBL621231 | 0.74 | EPHX2 (0.47) | FFAR4CHRM4EPHX2 | |
| SCHEMBL5287 | 0.73 | CHRM4 (0.44) | CHRM4EPHX2 | |
| SCHEMBL24227415 | 0.73 | USP2 (0.46) | FFAR4OPRL1EPHX2 | |
| SCHEMBL621627 | 0.73 | DRD2 (0.52) | DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488493-A1 | SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES | F. Hoffmann-La Roche AG (CH) | 2012-08-22 | — | — | EP | claimed |
| WO-2011045292-A1 | SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-04-21 | — | — | WO | claimed |