Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 7/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.45 |
| ▸ | RPS6KA5 | O75582 | 6/20 | 0.45 |
| ▸ | PRKG1 | Q13976 | 6/20 | 0.45 |
| ▸ | PKN2 | Q16513 | 6/20 | 0.45 |
| ▸ | GSK3A | P49840 | 6/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.45 |
| ▸ | SGK2 | Q9HBY8 | 5/20 | 0.45 |
| ▸ | PRKACA | P17612 | 5/20 | 0.45 |
| ▸ | PRKX | P51817 | 5/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.45 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | AKT1 | P31749 | 5/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.44 |
| ▸ | PRKG2 | Q13237 | 5/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6100258 | 0.90 | MMP13 (0.44) | MMP13GSK3BROCK1CLK4RPS6KA5 | |
| SCHEMBL5926234 | 0.85 | NPC1 (0.50) | HDAC1MTTPSMN1; SMN2PPARGTMEM97 | |
| SCHEMBL5927066 | 0.84 | MTTP (0.49) | HDAC1MTTPHDAC3PPARGTMEM97 | |
| SCHEMBL5927528 | 0.80 | PTPN1 (0.54) | MMP13GSK3BROCK1CLK4RPS6KA5 | |
| SCHEMBL5927266 | 0.77 | CYP26A1 (0.50) | MMP13GSK3BROCK1CLK4RPS6KA5 | |
| SCHEMBL5926229 | 0.77 | NPC1 (0.49) | HDAC1MTTPSMN1; SMN2PPARG | |
| SCHEMBL5927274 | 0.76 | HPGDS (0.50) | FFAR1MTTPSMN1; SMN2 | |
| SCHEMBL5926183 | 0.76 | MTTP (0.47) | HDAC1MTTPHDAC3PPARGTMEM97 | |
| SCHEMBL5926792 | 0.75 | FFAR1 (0.47) | FFAR1MTTPSMN1; SMN2PPARG | |
| SCHEMBL5926703 | 0.74 | MTTP (0.49) | MMP13HDAC1MTTPHDAC3PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060276518-A1 | Aryl and heteroaryl compounds and methods to modulate coagulation | TRANSTECH PHARMA, INC. | 2006-12-07 | — | — | US | disclosed |
| US-7122580-B2 | Aryl and heteroaryl compounds and methods to modulate coagulation | TRANSTECH PHARMA, INC. (US) | 2006-10-17 | — | — | US | disclosed |
| EP-1546089-A2 | ARYL AND HETEROARYL COMPOUNDS AND METHODS TO MODULATE COAGULATION | TransTech Pharma Inc. (US) | 2005-06-29 | — | — | EP | disclosed |
| US-20040110832-A1 | management, treatment and/or control of diseases caused in intrinsic clotting pathway utilizing factor IX such as stroke, myocardial infarction, aneurysm surgery, and deep vein thrombosis associated with surgical procedures etc | TRANSTECH PHARMA, LLC | 2004-06-10 | — | — | US | disclosed |
| WO-2004014844-A2 | ARYL AND HETEROARYL COMPOUNDS AND METHODS TO MODULATE COAGULATION | TRANSTECH PHARMA, INC. (US) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110832-A1 | management, treatment and/or control of diseases caused in intrinsic clotting pathway utilizing factor IX such as stroke, myocardial infarction, aneurysm surgery, and deep vein thrombosis associated with surgical procedures etc | TFPI, F9, TFPI2 | MMP13 147/4885GSK3B 303/4885ROCK1 972/4885 |
| US-20060276518-A1 | Aryl and heteroaryl compounds and methods to modulate coagulation | TFPI, F9, F2 | MMP13 464/4885GSK3B 259/4885ROCK1 2835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.