Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 6/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 5/20 | 0.43 |
| ▸ | PRKG1 | Q13976 | 5/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 5/20 | 0.43 |
| ▸ | GSK3A | P49840 | 5/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | SGK2 | Q9HBY8 | 4/20 | 0.43 |
| ▸ | PRKACA | P17612 | 4/20 | 0.43 |
| ▸ | PRKX | P51817 | 4/20 | 0.43 |
| ▸ | AKT1 | P31749 | 4/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.43 |
| ▸ | PRKG2 | Q13237 | 4/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.43 |
| ▸ | CDK1 | P06493 | 3/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5927532 | 0.90 | MMP13 (0.47) | MMP13GSK3BROCK1CLK4RPS6KA5 | |
| SCHEMBL5926229 | 0.87 | NPC1 (0.49) | MTTPHDAC1MEN1KMT2APPARG | |
| SCHEMBL5926183 | 0.86 | MTTP (0.47) | MTTPHDAC1HDAC3MEN1KMT2A | |
| SCHEMBL5927266 | 0.80 | CYP26A1 (0.50) | MMP13GSK3BROCK1CLK4RPS6KA5 | |
| SCHEMBL5926607 | 0.78 | CYP3A4 (0.47) | CYP26A1PPARG | |
| SCHEMBL5927528 | 0.77 | PTPN1 (0.54) | MMP13GSK3BROCK1CLK4RPS6KA5 | |
| SCHEMBL5927066 | 0.77 | MTTP (0.49) | MTTPHDAC1HDAC3MEN1KMT2A | |
| SCHEMBL5926234 | 0.77 | NPC1 (0.50) | MTTPHDAC1PPARGTMEM97SIGMAR1 | |
| SCHEMBL5926572 | 0.76 | RAB9A (0.47) | MTTPMEN1KMT2APPARG | |
| SCHEMBL5926349 | 0.76 | MAPK14 (0.47) | MTTPHDAC1HDAC3PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7122580-B2 | Aryl and heteroaryl compounds and methods to modulate coagulation | TRANSTECH PHARMA, INC. (US) | 2006-10-17 | — | — | US | disclosed |