Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5928992 | 0.81 | CYP3A4 (0.36) | CYP3A4CYP2D6KCNH2CNR2LMNA | |
| SCHEMBL5929060 | 0.81 | CYP3A4 (0.36) | CYP3A4CYP2D6KCNH2CNR2LMNA | |
| SCHEMBL5929000 | 0.78 | CYP3A4 (0.34) | CYP3A4CYP2D6KCNH2CNR2LMNA | |
| SCHEMBL5929210 | 0.78 | KDM4E (0.35) | CYP3A4CYP2D6KCNH2LMNAALDH1A1 | |
| SCHEMBL5929137 | 0.74 | ADORA2B (0.38) | KCNK3ALDH1A1HPGDPOLBKDM4E | |
| SCHEMBL5929331 | 0.73 | ALDH1A1 (0.33) | CYP3A4CYP2D6KCNH2LMNAKCNK3 | |
| SCHEMBL5929059 | 0.70 | KDM4E (0.33) | ALDH1A1KDM4ETSHRSMN1; SMN2MEN1 | |
| SCHEMBL5929248 | 0.70 | KDM4E (0.33) | LMNAPDCD1CD274ALDH1A1KDM4E | |
| SCHEMBL650379 | 0.69 | SIGMAR1 (0.39) | ALDH1A1MEN1KMT2A | |
| SCHEMBL5929127 | 0.68 | ALDH1A1 (0.35) | CYP3A4CYP2D6PDCD1CD274ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060154917-A1 | Substituted (heterocycloalkyl)methyl azole derivatives as c5a receptor modulators | NEUROGEN CORPORATION (US) | 2006-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060154917-A1 | Substituted (heterocycloalkyl)methyl azole derivatives as c5a receptor modulators | C5AR1, C5AR2, C3AR1 | CYP3A4 983/4885CYP2D6 1634/4885KCNH2 2944/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.