Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.70 |
| ▸ | RAB9A | P51151 | 6/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | TP53 | P04637 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | PKM | P14618 | 1/20 | 0.70 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.59 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5934206 | 0.93 | TRPV1 (0.61) | NPC1RAB9ASMN1; SMN2KMT2ATP53 | |
| SCHEMBL5934344 | 0.93 | TRPV1 (0.71) | NPC1RAB9ASMN1; SMN2KMT2ATP53 | |
| SCHEMBL5934465 | 0.90 | ROCK2 (0.58) | NPC1RAB9ASMN1; SMN2KMT2ATP53 | |
| SCHEMBL5934845 | 0.87 | KCNK3 (0.60) | NPC1RAB9ASMN1; SMN2KMT2ATP53 | |
| SCHEMBL5934235 | 0.86 | TRPV1 (0.59) | NPC1RAB9ASMN1; SMN2KMT2ATP53 | |
| SCHEMBL5934164 | 0.86 | SMN1; SMN2 (0.57) | NPC1RAB9ASMN1; SMN2KMT2ATP53 | |
| SCHEMBL5934518 | 0.86 | PLK1 (0.55) | NPC1RAB9ASMN1; SMN2KMT2ATP53 | |
| SCHEMBL5934558 | 0.86 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2KMT2ATP53 | |
| SCHEMBL16495372 | 0.86 | TRPV1 (0.64) | NPC1RAB9ASMN1; SMN2KMT2ATP53 | |
| SCHEMBL5934638 | 0.85 | TRPV1 (0.58) | NPC1RAB9ASMN1; SMN2KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060100245-A1 | Substituted biphenyl-4-carboxylic acid arylamide analogues | NEUROGEN CORPORATION (US) | 2006-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100245-A1 | Substituted biphenyl-4-carboxylic acid arylamide analogues | HCAR2, AHR, HCAR3 | NPC1 3100/4885RAB9A 1747/4885SMN1; SMN2 1592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.