Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.51 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.51 |
| ▸ | FRK | P42685 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 5/20 | 0.47 |
| ▸ | KDR | P35968 | 5/20 | 0.47 |
| ▸ | LCK | P06239 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5934416 | 0.89 | HDAC3 (0.57) | HDAC3HDAC8HDAC6MAPK14EPHA3 | |
| SCHEMBL5934657 | 0.86 | HDAC8 (0.54) | HDAC3HDAC8HDAC6SMN1; SMN2ALDH1A1 | |
| SCHEMBL5934188 | 0.86 | HDAC3 (0.56) | HDAC3HDAC8HDAC6SMN1; SMN2ALDH1A1 | |
| SCHEMBL5934109 | 0.85 | RAB9A (0.58) | SMN1; SMN2TP53ALDH1A1MEN1LMNA | |
| SCHEMBL5934471 | 0.85 | MEN1 (0.57) | HDAC3HDAC8HDAC6MAPK14SMN1; SMN2 | |
| SCHEMBL5934381 | 0.85 | HPGDS (0.55) | HDAC3HDAC8HDAC6SMN1; SMN2ALDH1A1 | |
| SCHEMBL5934592 | 0.85 | HDAC3 (0.55) | HDAC3HDAC8HDAC6SMN1; SMN2ALDH1A1 | |
| SCHEMBL5934509 | 0.84 | RAF1 (0.55) | HDAC3HDAC8HDAC6MAPK14EPHA3 | |
| SCHEMBL5934224 | 0.83 | TP53 (0.55) | HDAC3HDAC8HDAC6SMN1; SMN2TP53 | |
| SCHEMBL5934639 | 0.83 | HDAC8 (0.53) | HDAC3HDAC8HDAC6SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060100245-A1 | Substituted biphenyl-4-carboxylic acid arylamide analogues | NEUROGEN CORPORATION (US) | 2006-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100245-A1 | Substituted biphenyl-4-carboxylic acid arylamide analogues | HCAR2, AHR, HCAR3 | HDAC3 424/4885HDAC8 740/4885HDAC6 1243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.