Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 12/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5934416 | 0.84 | HDAC3 (0.57) | TRPV1HDAC3HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL5934518 | 0.84 | PLK1 (0.55) | TRPV1SMN1; SMN2NPC1RAB9APLK1 | |
| SCHEMBL5934188 | 0.83 | HDAC3 (0.56) | TRPV1HDAC3HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL12136750 | 0.83 | SMN1; SMN2 (0.56) | TRPV1SMN1; SMN2NPC1NFKB1RAB9A | |
| SCHEMBL5934585 | 0.81 | HDAC3 (0.55) | TRPV1HDAC3HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL5934657 | 0.80 | HDAC8 (0.54) | TRPV1HDAC3HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL5934477 | 0.79 | TRPV1 (0.56) | TRPV1HDAC3HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL5934381 | 0.79 | HPGDS (0.55) | TRPV1HDAC3HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL5934592 | 0.79 | HDAC3 (0.55) | TRPV1HDAC3HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL5934471 | 0.79 | MEN1 (0.57) | HDAC3HDAC8HDAC6SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060100245-A1 | Substituted biphenyl-4-carboxylic acid arylamide analogues | NEUROGEN CORPORATION (US) | 2006-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100245-A1 | Substituted biphenyl-4-carboxylic acid arylamide analogues | HCAR2, AHR, HCAR3 | TRPV1 53/4885HDAC3 424/4885HDAC8 740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.