Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LATS1 | O95835 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9886521 | 0.92 | MGAM (0.39) | MEN1KMT2ASMN1; SMN2MGAMGAA | |
| SCHEMBL12683544 | 0.82 | SMN1; SMN2 (0.41) | MEN1KMT2ASMN1; SMN2LATS1MGAM | |
| SCHEMBL8193799 | 0.79 | MAPT (0.43) | MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL14960649 | 0.79 | SMN1; SMN2 (0.40) | MEN1KMT2ASMN1; SMN2LATS1MGAM | |
| Hydrochloric Acid SCHEMBL2785831 | 0.79 | SMN1; SMN2 (0.40) | MEN1KMT2ASMN1; SMN2LATS1MGAM | |
| Hydrochloric Acid SCHEMBL32674100 | 0.79 | SMN1; SMN2 (0.40) | MEN1KMT2ASMN1; SMN2LATS1MGAM | |
| SCHEMBL8950840 | 0.79 | SMN1; SMN2 (0.40) | MEN1KMT2ASMN1; SMN2LATS1MGAM | |
| SCHEMBL27570845 | 0.78 | SMN1; SMN2 (0.38) | MEN1KMT2ASMN1; SMN2LATS1MGAM | |
| SCHEMBL28931135 | 0.78 | CYP2C19 (0.40) | MEN1KMT2ASMN1; SMN2LATS1MGAM | |
| SCHEMBL15461468 | 0.76 | ALDH1A1 (0.37) | MEN1KMT2ASMN1; SMN2LATS1MGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722727-B2 | Antifungal agents | Seynix, Inc. (US) | 2014-05-13 | — | — | US | disclosed |
| EP-2326180-B1 | ANTIFUNGAL AGENTS | MERCK SHARP & DOHME (US) | 2013-10-16 | — | — | EP | disclosed |
| US-8188085-B2 | Antifungal agents | MERCK SHARP & DOHME CORP. (US) | 2012-05-29 | — | — | US | disclosed |
| US-20120115848-A1 | Inhibitors of Polo-Like Kinase | ELAN PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | US | disclosed |
| US-20110224228-A1 | ANTIFUNGAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2011-09-15 | — | — | US | disclosed |
| US-20100113439-A1 | Antifungal agents | MERCK & CO., INC. (US) | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224228-A1 | ANTIFUNGAL AGENTS | GMDS, GBA3, UGGT1 | MEN1 718/4885KMT2A 4698/4885SMN1; SMN2 3959/4885 |
| US-20120115848-A1 | Inhibitors of Polo-Like Kinase | PLK1, POLR2E, POLR2H | MEN1 3607/4885KMT2A 1689/4885SMN1; SMN2 785/4885 |
| US-20100113439-A1 | Antifungal agents | GMDS, GBA3, UGGT1 | MEN1 736/4885KMT2A 4676/4885SMN1; SMN2 3768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.